Reactome | PF4(32-101) [extracellular region]

PF4(32-101) [extracellular region]

Stable Identifier

R-HSA-61823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

PF4, Platelet factor 4, PF-4, CXCL4, Oncostatin A, Iroplact

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02776 PF4

Gene Names

PF4, CXCL4, SCYB4

Chain

signal peptide:1-31, chain:32-101, chain:48-101

Reference Genes

BioGPS Gene:5196 PF4

COSMIC (genes):PF4 PF4

CTD Gene:5196 PF4

dbSNP Gene:5196 PF4

ENSEMBL:ENSG00000163737 PF4

ENSEMBL:ENSG00000163737.5 PF4

HGNC:8861 PF4

KEGG Gene (Homo sapiens):5196 PF4

Monarch:5196 PF4

NCBI Gene:5196 PF4

OMIM:173460 PF4

UCSC:P02776 PF4

Reference Transcript

RefSeq:NM_002619.3 PF4

Other Identifiers

1115_at

11727602_x_at

11758987_at

16976815

206390_PM_x_at

206390_x_at

2731376

2773349

2773350

2773351

2773352

2773353

2773354

5196

8100966

A_24_P79403

GE57889

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006351

GO:0006355

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007189

GO:0008009

GO:0008201

GO:0009605

GO:0010628

GO:0010744

GO:0012501

GO:0016525

GO:0019221

GO:0023052

GO:0030154

GO:0030168

GO:0030312

GO:0030593

GO:0030595

GO:0031012

GO:0031093

GO:0031410

GO:0032760

GO:0042060

GO:0042127

GO:0042832

GO:0043226

GO:0045236

GO:0045347

GO:0045651

GO:0045653

GO:0045944

GO:0048018

GO:0048248

GO:0048856

GO:0048870

GO:0051873

GO:0061844

GO:0062023

GO:0070098

GO:0071222

GO:0098542

GO:0098772

GO:2001240

HMNXSV003023616

HMNXSV003039140

M25897_at

PH_hs_0029008

TC04001281.hg

g4505732_3p_at

g4505732_3p_x_at

Participates

as a member of

Other forms of this molecule

PF4(32-101) [platelet alpha granule lumen]

PF4(48-101) [platelet alpha granule lumen]

PF4(48-101) [extracellular region]

Inferred To

cxcl-c5c [extracellular region] (Danio rerio)

cxcl8a.1 [extracellular region] (Xenopus tropicalis)

PF4(32-101) [extracellular region] (Danio rerio)

PF4(32-101) [extracellular region] (Gallus gallus)

PF4(32-101) [extracellular region] (Mus musculus)

PF4(32-101) [extracellular region] (Rattus norvegicus)

cxcl2 [extracellular region] (Xenopus tropicalis)

il8l1 [extracellular region] (Danio rerio)

CXCL8 [extracellular region] (Danio rerio)

CXCL8 [extracellular region] (Xenopus tropicalis)

cxcl8b.2 [extracellular region] (Xenopus tropicalis)

Homologues of PF4(32-101) [extracellular region] (Danio rerio)

Homologues of PF4(32-101) [extracellular region] (Xenopus tropicalis)

PPBP [extracellular region] (Bos taurus)

cxcl8a.2 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002610.1

OpenTargets

ENSG00000163737

GeneCards

P02776

HPA

ENSG00000163737-PF4

ZINC target

P02776

Ensembl

ENST00000296029, ENSP00000296029, ENSG00000163737

PRO

P02776

Pharos - Targets

P02776

Orphanet

24802

PDB

1F9Q, 1RHP, 4R9Y, 1F9R, 1DN3, 1PFM, 1F9S, 4RAU, 4R9W, 1PFN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10145 CXCL8	1	IL8 [extracellular region] (R-HSA-447095)	0.558	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	4
UniProt:Q99616 CCL13	1	CCL13 [extracellular region] (R-HSA-8862740)	0.558	2
UniProt:P78556 CCL20	1	CCL20(27-96) [extracellular region] (R-HSA-373097)	0.558	2
UniProt:P13500 CCL2	1	CCL2 [extracellular region] (R-HSA-443967)	0.558	2
UniProt:O15444 CCL25	1	CCL25 [extracellular region] (R-HSA-373096)	0.558	3
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	6