Reactome | GMPPA [cytosol]

GMPPA [cytosol]

Stable Identifier

R-HSA-532565

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mannose-1-phosphate guanyltransferase alpha, GMPPA_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        GMPPB converts Mannose-1-phosphate to GDP-Mannose (Homo sapiens)
        
        GMPP [cytosol] (Homo sapiens)
        
        GMPPA [cytosol] (Homo sapiens)
        
        GMPPA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96IJ6 GMPPA

Gene Names

GMPPA

Chain

chain:1-420

Reference Genes

BioGPS Gene:29926 GMPPA

COSMIC (genes):GMPPA GMPPA

CTD Gene:29926 GMPPA

dbSNP Gene:29926 GMPPA

ENSEMBL:ENSG00000144591 GMPPA

HGNC:22923 GMPPA

KEGG:hsa:29926 GMPPA

Monarch:29926 GMPPA

NCBI Gene:29926 GMPPA

OMIM:615495 GMPPA

UCSC:Q96IJ6 GMPPA

Reference Transcript

Other Identifiers

11744114_a_at

11747459_a_at

16891349

17122344

17122346

218070_PM_s_at

218070_s_at

2528617

2528618

2528619

2528621

2528622

2528623

2528624

2528625

2528626

2528627

2528628

2528629

2528630

2528631

2528632

2528633

2528634

2528635

2528636

2528637

2528638

2528639

2528640

2528641

2528642

2528643

2528644

2528646

2528647

29926

57166_at

8048595

A_14_P138737

A_21_P0011873

A_21_P0011874

A_23_P67913

A_24_P396800

GE55671

GO:0003824

GO:0004857

GO:0005515

GO:0005737

GO:0005829

GO:0006486

GO:0009058

GO:0009100

GO:0009298

GO:0012501

GO:0016740

GO:0019673

GO:0019899

GO:0021537

GO:0043226

GO:0048644

GO:0048856

GO:0050877

GO:0050890

GO:0050905

GO:0051402

GO:0055086

GO:0060538

GO:0061744

GO:0070062

GO:0098772

GO:0120508

GO:1901135

HMNXSV003006356

HMNXSV003033414

HMNXSV003034740

HMNXSV003050228

HMNXSV003054283

ILMN_1693878

ILMN_1804476

PH_hs_0002398

TC02001329.hg

TC02003843.hg

g11761616_3p_a_at

Participates

as a component of

GMPP [cytosol] (Homo sapiens)

Inferred To

gmppa [cytosol] (Xenopus tropicalis)

GMPPA [cytosol] (Bos taurus)

GMPPA [cytosol] (Caenorhabditis elegans)

GMPPA [cytosol] (Canis familiaris)

GMPPA [cytosol] (Danio rerio)

GMPPA [cytosol] (Dictyostelium discoideum)

GMPPA [cytosol] (Drosophila melanogaster)

GMPPA [cytosol] (Gallus gallus)

GMPPA [cytosol] (Mus musculus)

GMPPA [cytosol] (Rattus norvegicus)

GMPPA [cytosol] (Schizosaccharomyces pombe)

GMPPA [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000622191, ENSP00000340760, ENST00000683946, ENST00000373917, ENSP00000315925, ENSP00000350949, ENST00000373908, ENST00000341142, ENSP00000506941, ENSP00000363027, ENSP00000363016, ENSP00000478700, ENST00000313597, ENST00000358215

OpenTargets

ENSG00000144591

HPA

ENSG00000144591-GMPPA

PRO

Q96IJ6

Pharos - Targets

Q96IJ6

GlyGen

Q96IJ6

Orphanet

GMPPA

HMDB Protein

HMDBP03737

PDB

7D73, 7D74, 7D72

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3