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FANCM [nucleoplasm]
Stable Identifier
R-HSA-419535
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia group M protein, FANCM_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM binds FAAP24 (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IYD8 FANCM
Gene Names
FANCM, KIAA1596
Chain
chain:1-2048
Reference Genes
BioGPS Gene:57697 FANCM
COSMIC (genes):FANCM FANCM
CTD Gene:57697 FANCM
dbSNP Gene:57697 FANCM
ENSEMBL:ENSG00000187790 FANCM
HGNC:23168 FANCM
KEGG:hsa:57697 FANCM
Monarch:57697 FANCM
NCBI Gene:57697 FANCM
OMIM:609644 FANCM
UCSC:Q8IYD8 FANCM
Reference Transcript
RefSeq:NM_020937.3 FANCM
RefSeq:NM_001308134.1 FANCM
RefSeq:NM_001308133.1 FANCM
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 [nucleoplasm] (Homo sapiens)
as an input of
FANCM binds FAAP24 (Homo sapiens)
Other forms of this molecule
p-S1045-FANCM [nucleoplasm]
FANCM [cytosol]
Inferred To
fancm [nucleoplasm]
(Danio rerio)
fancm [nucleoplasm]
(Xenopus tropicalis)
Homologues of FANCM [nucleoplasm]
(Schizosaccharomyces pombe)
FANCM [nucleoplasm]
(Bos taurus)
FANCM [nucleoplasm]
(Canis familiaris)
FANCM [nucleoplasm]
(Dictyostelium discoideum)
FANCM [nucleoplasm]
(Drosophila melanogaster)
FANCM [nucleoplasm]
(Mus musculus)
FANCM [nucleoplasm]
(Saccharomyces cerevisiae)
FANCM [nucleoplasm]
(Schizosaccharomyces pombe)
FANCM [nucleoplasm]
(Sus scrofa)
Fancm [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of FANCM [nucleoplasm]
(Gallus gallus)
Cross References
ENSEMBL
ENST00000542564
,
ENST00000267430
,
ENSP00000442493
,
ENST00000556036
,
ENSP00000450596
,
ENSP00000267430
,
ENSG00000187790
OpenTargets
ENSG00000187790
GeneCards
FANCM
HPA
ENSG00000187790-FANCM
PRO
Q8IYD8
Pharos - Targets
Q8IYD8
GlyGen
Q8IYD8
Orphanet
FANCM
HMDB Protein
HMDBP11735
PDB
4DRB
,
4DAY
,
4M6W
,
4BXO
,
4E45
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTP7 FAAP24
2
FAAP24 [nucleoplasm]
(R-HSA-419533)
FAAP24 [cytosol]
(R-HSA-420798)
0.752
12
UniProt:Q8N2Z9 APITD1
2
APITD1 [cytosol]
(R-HSA-375310)
APITD1 [nucleoplasm]
(R-HSA-5633510)
0.641
4
UniProt:O95208-2 EPN2
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.539
5
UniProt:O15360 FANCA
2
FANCA [cytosol]
(R-HSA-420796)
FANCA [nucleoplasm]
(R-HSA-419541)
0.527
3
UniProt:Q8NB91 FANCB
2
FANCB [cytosol]
(R-HSA-420791)
FANCB [nucleoplasm]
(R-HSA-419528)
0.527
2
IntAct:EBI-12506732 SPLAYED
0.524
2
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