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APITD1 [cytosol]
Stable Identifier
R-HSA-375310
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CENP-S
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
FA core complex:HSP70s binds PKR (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
APITD1:STRA13 octamer [cytosol] (Homo sapiens)
APITD1:STRA13 [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
APITD1:STRA13 octamer [cytosol] (Homo sapiens)
APITD1:STRA13 [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
PKR forms a dimer (Homo sapiens)
FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
APITD1:STRA13 octamer [cytosol] (Homo sapiens)
APITD1:STRA13 [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
APITD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N2Z9 APITD1
Gene Names
APITD1, CENPS, FAAP16, MHF1
Chain
chain:1-138
Reference Genes
BioGPS Gene:100526739 APITD1
BioGPS Gene:378708 APITD1
COSMIC (genes):CENPS APITD1
CTD Gene:100526739 APITD1
CTD Gene:378708 APITD1
dbSNP Gene:100526739 APITD1
dbSNP Gene:378708 APITD1
ENSEMBL:ENSG00000175279 CENPS
HGNC:23163 APITD1
KEGG:hsa:100526739 APITD1
KEGG:hsa:378708 APITD1
Monarch:100526739 APITD1
Monarch:378708 APITD1
NCBI Gene:100526739 APITD1
NCBI Gene:378708 APITD1
OMIM:609130 APITD1
UCSC:Q8N2Z9 APITD1
Reference Transcript
RefSeq:NM_001270517.1 APITD1
RefSeq:NM_199006.2 APITD1
RefSeq:NM_198544.3 APITD1
RefSeq:NM_199294.2 APITD1
Other Identifiers
11740303_a_at
11743796_a_at
16658889
213454_PM_at
213454_at
2319834
2319835
2319836
2319840
2319841
2319842
2319845
2319846
2319848
2319849
2319850
2319851
2319852
36015_at
378708
A_23_P138023
A_33_P3300395
GO:0000712
GO:0000775
GO:0000776
GO:0000785
GO:0000939
GO:0003677
GO:0003682
GO:0003690
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006281
GO:0006974
GO:0007059
GO:0022414
GO:0031297
GO:0031398
GO:0036297
GO:0043226
GO:0043240
GO:0046982
GO:0051301
GO:0071821
HMNXSV003004664
HMNXSV003009267
HMNXSV003015237
HMNXSV003029943
Hs.44205.1.S1_3p_at
Hs.44205.1.S1_3p_x_at
ILMN_1788135
ILMN_1793360
TC01004175.hg
Participates
as a component of
APITD1:STRA13 [cytosol] (Homo sapiens)
CCAN network [cytosol] (Homo sapiens)
Other forms of this molecule
APITD1 [nucleoplasm]
Inferred To
cenps [cytosol]
(Xenopus tropicalis)
Cenps [cytosol]
(Mus musculus)
CENPS [cytosol]
(Bos taurus)
CENPS [cytosol]
(Canis familiaris)
CENPS [cytosol]
(Gallus gallus)
CENPS [cytosol]
(Sus scrofa)
Ghost homologue of APITD1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_950171.2
,
NP_954988.1
,
NP_940946.1
,
NP_001257446.1
OpenTargets
ENSG00000175279
ENSEMBL
ENSG00000175279
,
ENST00000309048
,
ENSP00000308583
HPA
ENSG00000175279-CENPS
GeneCards
CENPS
PRO
Q8N2Z9
Pharos - Targets
Q8N2Z9
PDB
4DRB
,
7R5S
,
4NE3
,
4NE6
,
4NE5
,
4NE1
,
4NDY
,
4E45
,
4E44
,
7XHN
,
7YWX
,
7XHO
,
4DRA
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IYD8 FANCM
3
p-S1045-FANCM [nucleoplasm]
(R-HSA-6788401)
FANCM [nucleoplasm]
(R-HSA-419535)
FANCM [cytosol]
(R-HSA-420802)
0.641
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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