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APITD1 [nucleoplasm]
Stable Identifier
R-HSA-5633510
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Centromere protein S, CENPS_HUMAN, CENPS, FAAP16, MHF1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Nucleosome assembly (Homo sapiens)
Deposition of new CENPA-containing nucleosomes at the centromere (Homo sapiens)
HJURP:CENPA complex localizes to the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
Mis18 complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
New CENPA-containing nucleosomes are deposited at the centromere (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
RSF complex binds the centromere (Homo sapiens)
CCAN:DNA:CASC5:Centromeric nucleosome:RSF complex [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA nucleosome [nucleoplasm] (Homo sapiens)
CCAN:DNA:CASC5 [nucleoplasm] (Homo sapiens)
CCAN [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
APITD1:STRA13 octamer [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
APITD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N2Z9 APITD1
Gene Names
APITD1, CENPS, FAAP16, MHF1
Chain
chain:1-138
Reference Genes
BioGPS Gene:100526739 APITD1
BioGPS Gene:378708 APITD1
COSMIC (genes):CENPS APITD1
CTD Gene:100526739 APITD1
CTD Gene:378708 APITD1
dbSNP Gene:100526739 APITD1
dbSNP Gene:378708 APITD1
ENSEMBL:ENSG00000175279 CENPS
HGNC:23163 APITD1
KEGG:hsa:100526739 APITD1
KEGG:hsa:378708 APITD1
Monarch:100526739 APITD1
Monarch:378708 APITD1
NCBI Gene:100526739 APITD1
NCBI Gene:378708 APITD1
OMIM:609130 APITD1
UCSC:Q8N2Z9 APITD1
Reference Transcript
RefSeq:NM_001270517.1 APITD1
RefSeq:NM_199006.2 APITD1
RefSeq:NM_198544.3 APITD1
RefSeq:NM_199294.2 APITD1
Other Identifiers
11740303_a_at
11743796_a_at
16658889
213454_PM_at
213454_at
2319834
2319835
2319836
2319840
2319841
2319842
2319845
2319846
2319848
2319849
2319850
2319851
2319852
36015_at
378708
A_23_P138023
A_33_P3300395
GO:0000712
GO:0000775
GO:0000776
GO:0000785
GO:0000939
GO:0003677
GO:0003682
GO:0003690
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006281
GO:0006974
GO:0007059
GO:0022414
GO:0031297
GO:0031398
GO:0036297
GO:0043226
GO:0043240
GO:0046982
GO:0051301
GO:0071821
HMNXSV003004664
HMNXSV003009267
HMNXSV003015237
HMNXSV003029943
Hs.44205.1.S1_3p_at
Hs.44205.1.S1_3p_x_at
ILMN_1788135
ILMN_1793360
TC01004175.hg
Participates
as a component of
CCAN [nucleoplasm] (Homo sapiens)
APITD1:STRA13 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
APITD1 [cytosol]
Inferred To
cenps [nucleoplasm]
(Danio rerio)
cenps [nucleoplasm]
(Xenopus tropicalis)
MHF1 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of APITD1 [nucleoplasm]
(Rattus norvegicus)
Cenps [nucleoplasm]
(Mus musculus)
CENPS [nucleoplasm]
(Bos taurus)
CENPS [nucleoplasm]
(Canis familiaris)
CENPS [nucleoplasm]
(Gallus gallus)
CENPS [nucleoplasm]
(Sus scrofa)
mhf1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_950171.2
,
NP_954988.1
,
NP_940946.1
,
NP_001257446.1
OpenTargets
ENSG00000175279
ENSEMBL
ENSG00000175279
,
ENST00000309048
,
ENSP00000308583
HPA
ENSG00000175279-CENPS
GeneCards
CENPS
PRO
Q8N2Z9
Pharos - Targets
Q8N2Z9
PDB
4DRB
,
7R5S
,
4NE3
,
4NE6
,
4NE5
,
4NE1
,
4NDY
,
4E45
,
4E44
,
7XHN
,
7YWX
,
7XHO
,
4DRA
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IYD8 FANCM
3
p-S1045-FANCM [nucleoplasm]
(R-HSA-6788401)
FANCM [nucleoplasm]
(R-HSA-419535)
FANCM [cytosol]
(R-HSA-420802)
0.641
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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