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FANCB [nucleoplasm]
Stable Identifier
R-HSA-419528
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Fanconi anemia group B protein, FANCB_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
Monoubiquitination of FANCD2:FANCI (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
POLN binds ICL-DNA (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Homo sapiens)
FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
FA core complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FANCB [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB91 FANCB
Gene Names
FANCB
Chain
initiator methionine:, chain:2-859
Reference Genes
BioGPS Gene:2187 FANCB
COSMIC (genes):FANCB FANCB
CTD Gene:2187 FANCB
dbSNP Gene:2187 FANCB
ENSEMBL:ENSG00000181544 FANCB
HGNC:3583 FANCB
KEGG:hsa:2187 FANCB
Monarch:2187 FANCB
NCBI Gene:2187 FANCB
OMIM:300515 FANCB
UCSC:Q8NB91 FANCB
Reference Transcript
RefSeq:NM_001324162.1 FANCB
RefSeq:NM_152633.3 FANCB
RefSeq:NM_001018113.2 FANCB
RefSeq:XM_017029355.1 FANCB
Other Identifiers
11735300_a_at
1553244_PM_at
1553244_at
1557217_PM_a_at
1557217_a_at
1557218_PM_s_at
1557218_s_at
17109211
2187
2326906
2840621
2840646
2867274
3136166
3404467
4000359
4000361
4000376
4000377
4000378
4000379
4000380
4000381
4000382
4000383
4000384
4000386
4000387
4000388
4000389
4000390
4000391
4000392
4000393
4000395
4000396
4000397
4000398
4000402
4000403
4000404
4000405
4000406
4000407
4000408
7893571
7894919
8171381
A_23_P356021
GE600362
GO:0000785
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006281
GO:0006310
GO:0036297
GO:0043226
GO:0043240
GO:1905168
GO:1990414
GO:2000042
HMNXSV003007108
Hs2.277254.1.S1_3p_at
Hs2.277254.2.S1_3p_s_at
ILMN_1698252
ILMN_1726756
PH_hs_0014239
TC0X000872.hg
Participates
as a component of
FA core complex [nucleoplasm] (Homo sapiens)
p-FA Core Complex [nucleoplasm] (Homo sapiens)
FA Core Complex [nucleoplasm] (Homo sapiens)
as an input of
FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)
Other forms of this molecule
FANCB [cytosol]
Inferred To
fancb [nucleoplasm]
(Xenopus tropicalis)
FANCB [nucleoplasm]
(Bos taurus)
FANCB [nucleoplasm]
(Canis familiaris)
FANCB [nucleoplasm]
(Gallus gallus)
FANCB [nucleoplasm]
(Sus scrofa)
Fancb [nucleoplasm]
(Mus musculus)
Fancb [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_689846.1
,
NP_001018123.1
,
NP_001311091.1
,
XP_016884844.1
OpenTargets
ENSG00000181544
ENSEMBL
ENSP00000512550
,
ENSP00000512577
,
ENSP00000512578
,
ENST00000324138
,
ENSP00000498215
,
ENSP00000326819
,
ENST00000696312
,
ENST00000696357
,
ENST00000650831
,
ENST00000696356
HPA
ENSG00000181544-FANCB
PRO
Q8NB91
Pharos - Targets
Q8NB91
Orphanet
FANCB
PDB
7KZQ
,
7KZP
,
7KZS
,
7KZT
,
7KZR
,
7KZV
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15360 FANCA
2
FANCA [cytosol]
(R-HSA-420796)
FANCA [nucleoplasm]
(R-HSA-419541)
0.643
4
UniProt:Q0VG06 FAAP100
2
FAAP100 [cytosol]
(R-HSA-420799)
FAAP100 [nucleoplasm]
(R-HSA-419545)
0.556
4
UniProt:Q8IYD8 FANCM
3
FANCM [cytosol]
(R-HSA-420802)
p-S1045-FANCM [nucleoplasm]
(R-HSA-6788401)
FANCM [nucleoplasm]
(R-HSA-419535)
0.527
2
UniProt:Q9NPD8 UBE2T
3
UBE2T [nucleoplasm]
(R-HSA-420942)
MonoUb-K91,K182-UBE2T [nucleoplasm]
(R-HSA-6785362)
Ub-C86-UBE2T [nucleoplasm]
(R-HSA-8864217)
0.527
2
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.527
2
UniProt:Q99615 DNAJC7
2
DNAJC7 [nucleoplasm]
(R-HSA-5255408)
DNAJC7 [cytosol]
(R-HSA-5252099)
0.527
2
UniProt:Q15435 PP1R7
0.508
2
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