Reactome | AP2S1-1 [endocytic vesicle membrane]

AP2S1-1 [endocytic vesicle membrane]

Stable Identifier

R-HSA-416630

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

AP2 complex subunit sigma-1, AP2S1 isoform 1

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
        
        Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
        
        AP2 complex [endocytic vesicle membrane] (Homo sapiens)
        
        AP2S1-1 [endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53680-1 AP2S1

Gene Names

AP2S1, AP17, CLAPS2

Other Identifiers

11716610_a_at

11716611_x_at

1175

11755456_a_at

16873647

202120_PM_x_at

202120_x_at

208074_PM_s_at

208074_s_at

211047_PM_x_at

211047_x_at

2483096

3866303

3866304

3866305

3866306

3866307

3866308

3866309

3866310

3866311

3866312

3866313

3866314

3866315

3866316

39347_at

8037847

A_24_P113295

A_33_P3346663

GE82612

GE86174

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0030100

GO:0030117

GO:0030122

GO:0030666

GO:0030669

GO:0031410

GO:0035615

GO:0036020

GO:0043226

GO:0043231

GO:0045202

GO:0045334

GO:0048268

GO:0048488

GO:0060090

GO:0065003

GO:0071944

GO:0072583

GO:0098793

GO:0098794

GO:0098884

HMNXSV003057421

ILMN_1662426

ILMN_1809957

PH_hs_0035544

TC19001658.hg

X97074_at

g11038642_3p_s_at

g13623468_3p_s_at

Participates

as a component of

AP2 complex [endocytic vesicle membrane] (Homo sapiens)

Inferred To

AP2S1 [endocytic vesicle membrane] (Bos taurus)

AP2S1 [endocytic vesicle membrane] (Canis familiaris)

AP2S1 [endocytic vesicle membrane] (Sus scrofa)

AP2S1-1 [endocytic vesicle membrane] (Gallus gallus)

Ap2s1 [endocytic vesicle membrane] (Mus musculus)

Ap2s1 [endocytic vesicle membrane] (Rattus norvegicus)

AP-2sigma [endocytic vesicle membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001288005.1, NP_067586.1, NP_001288010.1, NP_004060.2, NP_001288007.1

ENSEMBL

ENSP00000263270, ENST00000263270, ENSP00000470898, ENST00000601649

OpenTargets

ENSG00000042753

HPA

ENSG00000042753-AP2S1

PRO

P53680

Pharos - Targets

P53680

GlyGen

P53680

Orphanet

AP2S1

PDB

6URI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.725	6
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.643	4
UniProt:Q2M2I8 AAK1	1	AAK1 [cytosol] (R-HSA-8854795)	0.643	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	3
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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