Reactome | DPP4(39-766) [extracellular region]

DPP4(39-766) [extracellular region]

Stable Identifier

R-HSA-400517

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Dipeptidyl peptidase 4, soluble form, DPP4, DPP4_HUMAN, alternativeName: Dipeptidyl peptidase IV, shortName:DPP IV, alternativeName: T-cell activation antigen CD26, alternativeName: TP103, alternativeName: Adenosine deaminase complexing protein 2, alternativeName: ADABP CdAntigenNameCD26/CdAntigenName component, recommendedName: Dipeptidyl peptidase 4 soluble form, alternativeName: Dipeptidyl peptidase IV soluble form /component

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External Reference Information

External Reference

UniProt:P27487 DPP4

Gene Names

DPP4, ADCP2, CD26

Chain

chain:1-766, chain:39-766

Reference Genes

BioGPS Gene:1803 DPP4

COSMIC (genes):DPP4 DPP4

CTD Gene:1803 DPP4

dbSNP Gene:1803 DPP4

ENSEMBL:ENSG00000197635 DPP4

ENSEMBL:ENSG00000197635.11 DPP4

HGNC:3009 DPP4

KEGG Gene (Homo sapiens):1803 DPP4

Monarch:1803 DPP4

NCBI Gene:1803 DPP4

OMIM:102720 DPP4

UCSC:P27487 DPP4

Reference Transcript

RefSeq:NM_001935.3 DPP4

Other Identifiers

11756706_a_at

11758194_s_at

16904278

1803

203716_PM_s_at

203716_s_at

203717_PM_at

203717_at

211478_PM_s_at

211478_s_at

2584023

2584024

2584025

2584026

2584027

2584029

2584039

2584041

2584042

2584043

2584044

2584045

2584046

2584048

2584049

2584052

2584053

2584054

2584055

2584057

2584058

2584064

2584066

2584067

2584068

2584069

2584070

2584072

2584074

2584075

2584082

2584086

34823_at

8056222

A_24_P97104

A_33_P3287223

GE59864

GO:0001618

GO:0001662

GO:0001666

GO:0002020

GO:0002376

GO:0003824

GO:0004177

GO:0004252

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005773

GO:0005886

GO:0005925

GO:0006508

GO:0007155

GO:0008233

GO:0008236

GO:0008239

GO:0008284

GO:0009986

GO:0010716

GO:0016020

GO:0016192

GO:0016324

GO:0016486

GO:0016787

GO:0019065

GO:0030027

GO:0030139

GO:0030198

GO:0031258

GO:0031295

GO:0031410

GO:0033632

GO:0035641

GO:0036343

GO:0042110

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0043542

GO:0045121

GO:0045499

GO:0046581

GO:0046718

GO:0046813

GO:0048018

GO:0048870

GO:0050919

GO:0051604

GO:0061024

GO:0061025

GO:0070062

GO:0070161

GO:0090024

GO:0098772

GO:0110165

GO:0120116

GO:0140096

HMNXSV003021959

ILMN_1692535

PH_hs_0003256

TC02002478.hg

X60708_at

g180082_3p_a_at

g180082_3p_x_at

g181569_3p_a_at

g4503366_3p_at

Participates

as a component of

DPP4:DPP4 inhibitors [extracellular region] (Homo sapiens)

as an input of

DPP4 binds DPP4 inhibitors (Homo sapiens)

Other forms of this molecule

DPP4(1-766) [plasma membrane]

Inferred To

STE13 [extracellular region] (Saccharomyces cerevisiae)

DPP4(39-766) [extracellular region] (Canis familiaris)

DPP4(39-766) [extracellular region] (Danio rerio)

DPP4(39-766) [extracellular region] (Dictyostelium discoideum)

DPP4(39-766) [extracellular region] (Schizosaccharomyces pombe)

DAP2 [extracellular region] (Saccharomyces cerevisiae)

DPP4 [extracellular region] (Bos taurus)

DPP4 [extracellular region] (Gallus gallus)

DPP4 [extracellular region] (Sus scrofa)

fap [extracellular region] (Xenopus tropicalis)

Homologues of DPP4(39-766) [extracellular region] (Saccharomyces cerevisiae)

Homologues of DPP4(39-766) [extracellular region] (Schizosaccharomyces pombe)

Homologues of DPP4(39-766) [extracellular region] (Sus scrofa)

Dpp4 [extracellular region] (Mus musculus)

Dpp4 [extracellular region] (Rattus norvegicus)

dpf-2 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001926.2

ZINC - World Drugs

DPP4_HUMAN

Guide to Pharmacology - Targets

1612

OpenTargets

ENSG00000197635

ZINC - FDA approved

DPP4_HUMAN

ZINC - Substances

DPP4_HUMAN

ZINC - Biogenic

DPP4_HUMAN

ZINC target

P27487

PRO

P27487

PDB

3Q8W, 2RIP, 1R9M, 2QTB, 2OGZ, 2FJP, 1J2E, 3D4L, 3CCC, 1NU6, 4PV7, 2ONC, 5J3J, 3G0G, 3NOX, 1TKR, 2OPH, 2IIT, 5T4F, 3BJM, 3G0D, 2BGN, 3G0B, 2G5T, 2I78, 2RGU, 3C43, 3EIO, 3VJK, 2BUB, 4G1F, 1W1I, 2P8S, 2JID, 2G63, 3W2T, 3C45, 6B1E, 5Y7K, 5KBY, 4LKO, 2QOE, 3SWW, 5ISM, 3OPM, 2QKY, 2OAG, 3O95, 3HAC, 6B1O, 3F8S, 1U8E, 2OQI, 1NU8, 2QJR, 3G0C, 4DSA, 2OQV, 3QBJ, 5I7U, 1PFQ, 2OLE, 5T4B, 2IIV, 2I03, 1TK3, 1N1M, 4J3J, 3CCB, 4L72, 5ZID, 4N8D, 3VJM, 5Y7H, 3OC0, 3KWJ, 3Q0T, 3O9V, 1RWQ, 2G5P, 4KR0, 4JH0, 1WCY, 3VJL, 3KWF, 2BGR, 2HHA, 5T4H, 4DTC, 3HAB, 3WQH, 1R9N, 1X70, 3H0C, 5Y7J, 4DSZ, 4A5S, 5T4E, 2AJL, 4N8E, 2QT9, 4PNZ, 4QZV, 3SX4

ZINC - Investigational

DPP4_HUMAN

GeneCards

P27487

HPA

ENSG00000197635-DPP4

Ensembl

ENST00000360534, ENSP00000353731, ENSG00000197635

Pharos - Targets

P27487

ZINC - Predictions - Purchasable

DPP4_HUMAN

HMDB Protein

HMDBP01651

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:K9N5Q8 SPIKE			0.842	7
UniProt:K0BRG7 K0BRG7			0.74	5
UniProt:P19875 CXCL2	1	CXCL2(35-107) [extracellular region] (R-HSA-373777)	0.623	2
UniProt:P51671 CCL11	1	CCL11 [extracellular region] (R-HSA-443966)	0.623	2
UniProt:O14625 CXCL11	1	CXCL11 [extracellular region] (R-HSA-373852)	0.623	2
UniProt:P02778 CXCL10	1	CXCL10(22-98) [extracellular region] (R-HSA-373853)	0.623	2
UniProt:Q07325 CXCL9	1	CXCL9 [extracellular region] (R-HSA-373856)	0.623	2
UniProt:P27487 DPP4	2	DPP4(39-766) [extracellular region] (R-HSA-400517) DPP4(1-766) [plasma membrane] (R-HSA-400527)	0.611	12
UniProt:R9UQ53 R9UQ53			0.602	3
UniProt:A0A2R4KP93 A0A2R4KP93			0.558	2
UniProt:Q14416 GRM2	1	GRM2 [plasma membrane] (R-HSA-420468)	0.524	2