Reactome | CXCL11 [extracellular region]

CXCL11 [extracellular region]

Stable Identifier

R-HSA-373852

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C-X-C motif chemokine 11, CXL11_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL11 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14625 CXCL11

Gene Names

CXCL11, ITAC, SCYB11, SCYB9B

Chain

signal peptide:1-21, chain:22-94

Reference Genes

BioGPS Gene:6373 CXCL11

COSMIC (genes):CXCL11 CXCL11

CTD Gene:6373 CXCL11

dbSNP Gene:6373 CXCL11

ENSEMBL:ENSG00000169248 CXCL11

ENSEMBL:ENSG00000169248.13 CXCL11

HGNC:10638 CXCL11

KEGG Gene (Homo sapiens):6373 CXCL11

Monarch:6373 CXCL11

NCBI Gene:6373 CXCL11

OMIM:604852 CXCL11

UCSC:O14625 CXCL11

Reference Transcript

Other Identifiers

11732466_a_at

11732467_x_at

11749245_a_at

16977058

211122_PM_s_at

211122_s_at

2773973

2773976

2773977

2773978

2773980

2773981

2773982

2773983

6373

8101131

A_24_P20607

GE79842

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007189

GO:0007267

GO:0008009

GO:0008201

GO:0009605

GO:0010818

GO:0023052

GO:0030593

GO:0042127

GO:0045236

GO:0048018

GO:0048248

GO:0048870

GO:0051281

GO:0055065

GO:0055085

GO:0061844

GO:0070098

GO:0071222

GO:0098542

GO:0098772

HMNXSV003010504

ILMN_2067895

PH_hs_0005769

TC04001306.hg

TC04002601.hg

U59286_at

g2580585_3p_a_at

Participates

as a member of

CXCR3 ligands [extracellular region] (Homo sapiens)

Inferred To

LOC100334604 [extracellular region] (Danio rerio)

cxcl11.6 [extracellular region] (Danio rerio)

Cxcl11 [extracellular region] (Mus musculus)

Cxcl11 [extracellular region] (Rattus norvegicus)

cxc64 [extracellular region] (Danio rerio)

Homologues of CXCL11 [extracellular region] (Danio rerio)

CXCL11 [extracellular region] (Bos taurus)

CXCL11 [extracellular region] (Canis familiaris)

CXCL11 [extracellular region] (Danio rerio)

CXCL11 [extracellular region] (Sus scrofa)

LOC567656 [extracellular region] (Danio rerio)

cxcl11.1 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_005400.1, NP_001289052.1

OpenTargets

ENSG00000169248

GeneCards

O14625

HPA

ENSG00000169248-CXCL11

Ensembl

ENST00000306621, ENSP00000306884, ENSP00000425819, ENSG00000169248, ENST00000503860

PRO

O14625

Pharos - Targets

O14625

HMDB Protein

HMDBP07644

PDB

1RJT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27487 DPP4	2	DPP4(39-766) [extracellular region] (R-HSA-400517) DPP4(1-766) [plasma membrane] (R-HSA-400527)	0.623	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	3
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2