Reactome | CXCL2(35-107) [extracellular region]

CXCL2(35-107) [extracellular region]

Stable Identifier

R-HSA-373777

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL2, Macrophage inflammatory protein 2-alpha, MIP2A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19875 CXCL2

Gene Names

CXCL2, GRO2, GROB, MIP2A, SCYB2

Chain

signal peptide:1-34, chain:35-107, chain:39-107

Reference Genes

BioGPS Gene:2920 CXCL2

COSMIC (genes):CXCL2 CXCL2

CTD Gene:2920 CXCL2

dbSNP Gene:2920 CXCL2

ENSEMBL:ENSG00000081041 CXCL2

HGNC:4603 CXCL2

KEGG Gene (Homo sapiens):2920 CXCL2

Monarch:2920 CXCL2

NCBI Gene:2920 CXCL2

OMIM:139110 CXCL2

UCSC:P19875 CXCL2

Reference Transcript

RefSeq:NM_002089.3 CXCL2

Other Identifiers

11744127_at

11744128_x_at

16976844

209774_x_at

2731385

2773395

2773396

2773435

2773436

2773437

2773438

2773439

2773443

2773445

2773447

2920

37187_at

8100994

A_23_P315364

A_24_P257416

GE61290

GO:0002237

GO:0002376

GO:0003674

GO:0005125

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006935

GO:0006950

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0008009

GO:0008150

GO:0019221

GO:0030593

GO:0040011

GO:0045236

GO:0048870

GO:0060326

GO:0061844

GO:0070098

GO:0071222

HMNXSV003030638

ILMN_1682636

M57731_s_at

PH_hs_0035459

TC04001286.hg

g183626_3p_at

g183626_3p_x_at

Participates

as a member of

Inferred To

XB5945946 [provisional:cxcl8] [extracellular region] (Xenopus tropicalis)

Cxcl2 [extracellular region] (Mus musculus)

Cxcl2 [extracellular region] (Rattus norvegicus)

Homologues of CXCL1(35-107) [extracellular region] (Danio rerio)

Homologues of CXCL1(35-107) [extracellular region] (Gallus gallus)

Homologues of CXCL1(35-107) [extracellular region] (Mus musculus)

Homologues of CXCL1(35-107) [extracellular region] (Rattus norvegicus)

Homologues of CXCL1(35-107) [extracellular region] (Xenopus tropicalis)

cxcl8b.1 [extracellular region] (Danio rerio)

Cxcl3 [extracellular region] (Mus musculus)

Cxcl3 [extracellular region] (Rattus norvegicus)

CXCL8 [extracellular region] (Danio rerio)

CXCL8 [extracellular region] (Gallus gallus)

Cxcl1 [extracellular region] (Mus musculus)

Cxcl1 [extracellular region] (Rattus norvegicus)

cxcl8b.3 [extracellular region] (Danio rerio)

cxcl19 [extracellular region] (Danio rerio)

LOC422654 [extracellular region] (Gallus gallus)

LOC100498389 [extracellular region] (Xenopus tropicalis)

LOC100525396 [extracellular region] (Sus scrofa)

LOC101883994 [extracellular region] (Danio rerio)

k60 [extracellular region] (Gallus gallus)

CXCL13L2 [extracellular region] (Gallus gallus)

cxcl8a [extracellular region] (Danio rerio)

CXCL13L3 [extracellular region] (Gallus gallus)

CXCL13 [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_002080.1

OpenTargets

ENSG00000081041

HPA

ENSG00000081041-CXCL2

GeneCards

P19875

Ensembl

ENST00000508487, ENSG00000081041, ENSP00000427279

PRO

P19875

Pharos - Targets

P19875

PDB

1QNK, 5OB5

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27487 DPP4	2	DPP4(1-766) [plasma membrane] (R-HSA-400527) DPP4(39-766) [extracellular region] (R-HSA-400517)	0.623	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2