Reactome | CXCL2(35-107) [extracellular region]

CXCL2(35-107)

Stable Identifier

R-HSA-373777

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL2, Macrophage inflammatory protein 2-alpha, MIP2A_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gi [extracellular region] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL2(35-107) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19875 CXCL2

Gene Names

CXCL2, GRO2, GROB, MIP2A, SCYB2

Chain

signal peptide:1-34, chain:35-107, chain:39-107

Reference Genes

BioGPS Gene:2920 CXCL2

COSMIC (genes):CXCL2 CXCL2

CTD Gene:2920 CXCL2

dbSNP Gene:2920 CXCL2

ENSEMBL:ENSG00000081041 CXCL2

HGNC:4603 CXCL2

KEGG Gene (Homo sapiens):hsa:2920 CXCL2

Monarch:2920 CXCL2

NCBI Gene:2920 CXCL2

OMIM:139110 CXCL2

UCSC:P19875 CXCL2

Reference Transcript

RefSeq:NM_002089.3 CXCL2

Other Identifiers

11744127_at

11744128_x_at

16976844

1QNK

209774_x_at

2920

37187_at

8100994

A0A024RDD9

A_23_P315364

A_24_P257416

AAA63182

AAA63183

AAC03540

AAH15753

AF043340

BC015753

CAA37808

CAG46968

CCDS34008

CH471057

CR542171

CXCL2

CXCL2-202

EAX05700

EAX05701

ENSG00000081041

ENSP00000427279

ENST00000508487

EntrezGene:2920

g183626_3p_at

g183626_3p_x_at

GE61290

GO:0002237

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007186

GO:0008009

GO:0032496

GO:0042127

GO:0045236

GO:0060326

GO:0070098

GO:0090023

HGNC:4603

Hs.75765

ILMN_1682636

IPR001089

IPR001811

IPR018048

M36820

M57731

M57731_s_at

MIM:139110

NM_002089

NP_002080

PF00048

PH_hs_0035459

PR00436

PR00437

SM00199

TC04001286.hg

uc003hhm.5

UPI0000047AA8

X53799

Participant Of

hasMember

Inferred To

Homologues of CXCL1(35-107) [extracellular region] (Bos taurus)

Homologues of CXCL1(35-107) [extracellular region] (Mus musculus)

Homologues of CXCL1(35-107) [extracellular region] (Rattus norvegicus)

Homologues of CXCL1(35-107) [extracellular region] (Sus scrofa)

Homologues of CXCL1(35-107) [extracellular region] (Taeniopygia guttata)

CXCL1(35-107) [extracellular region] (Bos taurus)

CXCL1(35-107) [extracellular region] (Danio rerio)

CXCL1(35-107) [extracellular region] (Mus musculus)

CXCL1(35-107) [extracellular region] (Rattus norvegicus)

CXCL1(35-107) [extracellular region] (Sus scrofa)

CXCL1(35-107) [extracellular region] (Taeniopygia guttata)

Cross References

RefSeq

NP_002080.1

GeneCards

P19875

PRO

P19875

PDB

1QNK, 5OB5

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27487 DPP4	2	DPP4(1-766) [plasma membrane] (R-HSA-400527) DPP4(39-766) [extracellular region] (R-HSA-400517)	0.623	2