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CXCL2(35-107) [extracellular region]
Stable Identifier
R-HSA-373777
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CXCL2, Macrophage inflammatory protein 2-alpha, MIP2A_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
CXCL2(35-107) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19875 CXCL2
Gene Names
CXCL2, GRO2, GROB, MIP2A, SCYB2
Chain
signal peptide:1-34, chain:35-107, chain:39-107
Reference Genes
BioGPS Gene:2920 CXCL2
COSMIC (genes):CXCL2 CXCL2
CTD Gene:2920 CXCL2
dbSNP Gene:2920 CXCL2
ENSEMBL:ENSG00000081041 CXCL2
ENSEMBL:ENSG00000081041.9 CXCL2
HGNC:4603 CXCL2
KEGG Gene (Homo sapiens):2920 CXCL2
Monarch:2920 CXCL2
NCBI Gene:2920 CXCL2
OMIM:139110 CXCL2
UCSC:P19875 CXCL2
Reference Transcript
RefSeq:NM_002089.3 CXCL2
Other Identifiers
11744127_at
11744128_x_at
16976844
209774_PM_x_at
209774_x_at
2731385
2773395
2773396
2773435
2773436
2773437
2773438
2773439
2773443
2773445
2773447
2920
37187_at
8100994
A_23_P315364
A_24_P257416
GE61290
GO:0002237
GO:0002376
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006952
GO:0006954
GO:0006955
GO:0007165
GO:0008009
GO:0009605
GO:0023052
GO:0030593
GO:0045236
GO:0048018
GO:0048870
GO:0060326
GO:0061844
GO:0070098
GO:0071222
GO:0098542
GO:0098772
HMNXSV003030638
ILMN_1682636
M57731_s_at
PH_hs_0035459
TC04001286.hg
g183626_3p_at
g183626_3p_x_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CXCR2 ligands [extracellular region] (Homo sapiens)
Inferred To
Cxcl2 [extracellular region]
(Mus musculus)
Cxcl2 [extracellular region]
(Rattus norvegicus)
cxcl8a.1 [extracellular region]
(Xenopus tropicalis)
cxcl2 [extracellular region]
(Xenopus tropicalis)
il8l1 [extracellular region]
(Danio rerio)
Homologues of CXCL1(35-107) [extracellular region]
(Bos taurus)
Homologues of CXCL1(35-107) [extracellular region]
(Danio rerio)
Homologues of CXCL1(35-107) [extracellular region]
(Mus musculus)
Homologues of CXCL1(35-107) [extracellular region]
(Rattus norvegicus)
Homologues of CXCL1(35-107) [extracellular region]
(Xenopus tropicalis)
Cxcl3 [extracellular region]
(Mus musculus)
Cxcl3 [extracellular region]
(Rattus norvegicus)
CXCL8 [extracellular region]
(Danio rerio)
CXCL8 [extracellular region]
(Xenopus tropicalis)
Cxcl1 [extracellular region]
(Mus musculus)
Cxcl1 [extracellular region]
(Rattus norvegicus)
cxcl8b.2 [extracellular region]
(Xenopus tropicalis)
cxcl-c5c [extracellular region]
(Danio rerio)
CXCL3 [extracellular region]
(Bos taurus)
cxcl8a.2 [extracellular region]
(Xenopus tropicalis)
CXCL1(35-107) [extracellular region]
(Bos taurus)
CXCL1(35-107) [extracellular region]
(Danio rerio)
CXCL1(35-107) [extracellular region]
(Gallus gallus)
CXCL1(35-107) [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_002080.1
OpenTargets
ENSG00000081041
GeneCards
P19875
HPA
ENSG00000081041-CXCL2
Ensembl
ENST00000508487
,
ENSP00000427279
,
ENSG00000081041
PRO
P19875
Pharos - Targets
P19875
PDB
1QNK
,
5OB5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27487 DPP4
2
DPP4(39-766) [extracellular region]
(R-HSA-400517)
DPP4(1-766) [plasma membrane]
(R-HSA-400527)
0.623
2
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
2
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
2
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