Reactome | CXCL10(22-98) [extracellular region]

CXCL10(22-98) [extracellular region]

Stable Identifier

R-HSA-373853

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

CXCL10, C-X-C motif chemokine 10, CXL10_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)
        
        CXCR3:CXCR3 ligands [plasma membrane] (Homo sapiens)
        
        CXCR3 ligands [extracellular region] (Homo sapiens)
        
        CXCL10(22-98) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02778 CXCL10

Gene Names

CXCL10, INP10, SCYB10

Chain

signal peptide:1-21, chain:22-98, chain:22-94

Reference Genes

BioGPS Gene:3627 CXCL10

COSMIC (genes):CXCL10 CXCL10

CTD Gene:3627 CXCL10

dbSNP Gene:3627 CXCL10

ENSEMBL:ENSG00000169245 CXCL10

ENSEMBL_homo_sapiens_GENE:ENSG00000169245.6 CXCL10

HGNC:10637 CXCL10

KEGG Gene (Homo sapiens):3627 CXCL10

Monarch:3627 CXCL10

NCBI Gene:3627 CXCL10

OMIM:147310 CXCL10

UCSC:P02778 CXCL10

Reference Transcript

RefSeq:NM_001565.3 CXCL10

Other Identifiers

11720298_at

16977052

204533_PM_at

204533_at

2773961

2773963

2773966

2773967

2773970

2773971

3627

431_at

8101126

A_24_P303091

A_33_P3343175

GE59642

GO:0002376

GO:0002690

GO:0003013

GO:0005102

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007166

GO:0007186

GO:0007189

GO:0007267

GO:0007517

GO:0008009

GO:0008015

GO:0008201

GO:0008284

GO:0008603

GO:0009617

GO:0009897

GO:0010332

GO:0010818

GO:0010819

GO:0010996

GO:0012501

GO:0016525

GO:0023052

GO:0030154

GO:0030335

GO:0030593

GO:0032496

GO:0033280

GO:0034605

GO:0042056

GO:0042118

GO:0042127

GO:0042981

GO:0045236

GO:0045662

GO:0045944

GO:0048018

GO:0048248

GO:0048856

GO:0048870

GO:0050918

GO:0051281

GO:0051607

GO:0055065

GO:0055085

GO:0061844

GO:0070098

GO:0071222

GO:0090026

GO:0097398

GO:0098542

GO:0098586

GO:0098772

GO:0140374

GO:1901509

GO:1901740

GO:2000406

HMNXSV003029610

ILMN_1791759

PH_hs_0024961

TC04001305.hg

X02530_at

g4504700_3p_at

Participates

as a member of

Inferred To

cxcl8b.1 [extracellular region] (Danio rerio)

k60 [extracellular region] (Gallus gallus)

CXCL8 [extracellular region] (Gallus gallus)

Cxcl10 [extracellular region] (Mus musculus)

Cxcl10 [extracellular region] (Rattus norvegicus)

Homologues of CXCL10(22-98) [extracellular region] (Danio rerio)

Homologues of CXCL10(22-98) [extracellular region] (Gallus gallus)

cxcl8b.3 [extracellular region] (Danio rerio)

CXCL10 [extracellular region] (Bos taurus)

CXCL10 [extracellular region] (Canis familiaris)

CXCL10 [extracellular region] (Sus scrofa)

CXCL10(22-98) [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_001556.2

OpenTargets

ENSG00000169245

HPA

ENSG00000169245-CXCL10

GeneCards

P02778

Ensembl

ENST00000306602, ENSG00000169245, ENSP00000305651

PRO

P02778

Pharos - Targets

P02778

PDB

1LV9, 1O7Z, 8K2X, 1O7Y, 1O80

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27487 DPP4	2	DPP4(39-766) [extracellular region] (R-HSA-400517) DPP4(1-766) [plasma membrane] (R-HSA-400527)	0.623	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	2