Reactome | CLOCK [cytosol]

CLOCK [cytosol]

Stable Identifier

R-HSA-400392

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Circadian locomoter output cycles protein kaput, CLOCK_HUMAN

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External Reference Information

External Reference

UniProt:O15516 CLOCK

Gene Names

CLOCK, BHLHE8, KIAA0334

Chain

chain:1-846

Reference Genes

BioGPS Gene:9575 CLOCK

COSMIC (genes):CLOCK CLOCK

CTD Gene:9575 CLOCK

dbSNP Gene:9575 CLOCK

ENSEMBL:ENSG00000134852 CLOCK

HGNC:2082 CLOCK

KEGG:hsa:9575 CLOCK

Monarch:9575 CLOCK

NCBI Gene:9575 CLOCK

OMIM:601851 CLOCK

UCSC:O15516 CLOCK

Reference Transcript

Other Identifiers

11727626_a_at

11749633_a_at

16976072

16976074

204980_PM_at

204980_at

225856_PM_at

225856_at

227531_PM_at

227531_at

2769942

2769944

2769946

2769948

2769949

2769950

2769951

2769952

2769953

2769956

2769957

2769958

2769959

2769960

2769961

2769962

2769970

2769971

2769974

2769975

2769976

2769977

2769978

2769979

2769980

2769981

2769984

2769985

2769986

2769987

2769988

2769989

2769990

2769991

2769992

2769993

2769994

2769995

2769999

2770010

2770011

2770012

36080_at

51997_at

51998_at

764_s_at

8100428

9575

AB002332_at

AB005535_s_at

A_23_P419038

A_24_P166168

A_33_P3358938

GE53063

GE774315

GO:0000077

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0003824

GO:0004402

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006355

GO:0006357

GO:0006473

GO:0006974

GO:0007165

GO:0007283

GO:0007623

GO:0009648

GO:0016740

GO:0016746

GO:0022414

GO:0030163

GO:0031490

GO:0032922

GO:0033391

GO:0042634

GO:0042752

GO:0042753

GO:0043161

GO:0043226

GO:0043231

GO:0043565

GO:0045892

GO:0045893

GO:0045944

GO:0046983

GO:0048511

GO:0050729

GO:0050796

GO:0051092

GO:0051775

GO:0061733

GO:0070888

GO:0071479

GO:0140096

GO:0140110

GO:1990513

GO:1990837

GO:2000074

GO:2000323

HMNXSV003045622

Hs.40289.0.A1_3p_at

Hs.40289.1.S1_3p_at

ILMN_1682399

ILMN_1869087

PH_hs_0003028

PH_hs_0025553

TC04001211.hg

TC04001212.hg

TC04002556.hg

g4758009_3p_at

Participates

as an output of

Expression of CLOCK (Homo sapiens)

as a member of

CLOCK,NPAS2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S-CLOCK [nucleoplasm]

CLOCK [nucleoplasm]

Cross References

RefSeq

NP_001254772.1, XP_016864343.1, NP_004889.1, XP_011532711.1, XP_011532712.1, XP_011532713.1, XP_005265844.1

Guide to Pharmacology - Targets

2649

OpenTargets

ENSG00000134852

ENSEMBL

ENST00000309964, ENST00000381322, ENSP00000370723, ENSP00000426983, ENST00000513440, ENSP00000308741

HPA

ENSG00000134852-CLOCK

PRO

O15516

Pharos - Targets

O15516

GlyGen

O15516

PDB

6QPJ, 4H10

HMDB Protein

HMDBP11569

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00327 ARNTL	3	ARNTL [nucleoplasm] (R-HSA-9634872) ARNTL [cytosol] (R-HSA-400353) p-S-ARNTL [nucleoplasm] (R-HSA-421312)	0.796	7
UniProt:O00327-8 BMAL1			0.72	6
UniProt:Q8WYA1-3 BMAL2			0.666	4
UniProt:P97784 Cry1	4	ub-p-Cry1 [nucleoplasm] (R-MMU-517961) p-Cry1 [nucleoplasm] (R-MMU-508662) p-Cry1 [cytosol] (R-MMU-508644) Cry1 [cytosol] (R-MMU-508637)	0.547	2
UniProt:Q8WYA1 ARNTL2	1	ARNTL2 [nucleoplasm] (R-HSA-879826)	0.547	4
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.527	3
UniProt:Q9C0C6 CIPC			0.527	3
UniProt:Q8WW24 TEKT4			0.527	3