Reactome | p-S90-BMAL1 [cytosol]

p-S90-BMAL1 [cytosol]

Stable Identifier

R-HSA-9912391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S90-ARNTL, fullName evidence="31"Basic helix-loop-helix ARNT-like protein 1, BMAL1_HUMAN

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External Reference Information

External Reference

UniProt:O00327 BMAL1

Gene Names

BMAL1, ARNTL, BHLHE5, MOP3, PASD3

Chain

chain:1-626

Reference Genes

COSMIC (genes):ARNTL BMAL1

dbSNP Gene:406 BMAL1

ENSEMBL:ENSG00000133794 BMAL1

Participates

as an output of

CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 (Homo sapiens)

as an input of

p-S90-BMAL1 binds p-T451,T461-CLOCK (Homo sapiens)

as a component of

p-S90-BMAL1:p-T451,T461-CLOCK [cytosol] (Homo sapiens)

Other forms of this molecule

p-S90,Ac-K538-BMAL1 [nucleoplasm]

ARNTL [nucleoplasm]

p-S-ARNTL [nucleoplasm]

ARNTL [cytosol]

p-S90-BMAL1 [nucleoplasm]

Modified Residues

Name

O-phospho-L-serine at 90

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15516 CLOCK	7	p-T451,T461-CLOCK [nucleoplasm] (R-HSA-9920699) p-T451,T461-CLOCK [cytosol] (R-HSA-9912397) CLOCK [cytosol] (R-HSA-400392) p-S-CLOCK [nucleoplasm] (R-HSA-421310) CLOCK [nucleoplasm] (R-HSA-879828) p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (R-HSA-9920715) p-S,T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (R-HSA-9922270)	0.796	7
UniProt:Q99743 NPAS2	2	NPAS2 [cytosol] (R-HSA-400314) p-NPAS2 [nucleoplasm] (R-HSA-421309)	0.632	4
UniProt:D0VY79 D0VY79			0.556	3
UniProt:Q9Y463 DYR1B			0.527	2

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