Cdk5 phosphorylates CLOCK on serine 451 and serine-461

Stable Identifier
R-NUL-9932082
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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High
 | PPTX  | SBGN
Cdk5 phosphorylates CLOCK on serine 451 and serine-461
Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on serine-451 and serine-461 (assayed with mouse Cdk5 and human CLOCK in Kwak et al. 2013). The phosphorylation causes nuclear translocation of CLOCK and increases transcriptional activation by the BMAL1:CLOCK complex (Kwak et al. 2013).
Literature References
PubMed ID Title Journal Year
24235147 Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation

Kwak, Y, Jeong, J, Lee, S, Park, YU, Lee, SA, Han, DH, Kim, JH, Ohshima, T, Mikoshiba, K, Suh, YH, Cho, S, Park, SK

J Biol Chem 2013
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Cdk5 [cytosol]

Physical Entity
Cdk5 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK5 phosphorylates CLOCK on serine-451 and serine-461 (Homo sapiens)
Authored
May, B  (2024-12-15)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-17)
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