RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK

Stable Identifier
R-HSA-9932070
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK
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Inferred from mouse homologs, RAI1 increases transcription of the CLOCK gene (Williams et al. 2012). The CLOCK gene is transcribed (Steeves et al. 1999) in a circadian pattern to yield mRNA and the mRNA is translated to yield CLOCK protein (inferred from mouse homologs). The promoter of the CLOCK gene contains a ROR response element (RRE, RORE) that can bind either RORA or RORC, both of which enhance transcription of CLOCK (inferred from mouse homologs). Transcription of CLOCK is repressed by REV-ERBA (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
10198158 Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei

Steeves, TD, King, DP, Zhao, Y, Sangoram, AM, Du, F, Bowcock, AM, Moore, RY, Takahashi, JS

Genomics 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
SIRT1 [nucleoplasm] (Homo sapiens)
Regulator
RAI1 [nucleoplasm] (Homo sapiens)
Regulator
RORA,C:Coactivators:CLOCK gene [nucleoplasm] (Homo sapiens)
Active Unit
RORA,RORC [nucleoplasm]
Inferred From
Rora,c and coactivators positively regulate expression of Clock (Mus musculus)
Authored
May, B  (2024-12-17)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-12-17)
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