CLOCK gene produces CLOCK

Stable Identifier
R-HSA-1368119
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Synonyms
Expression of CLOCK
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CLOCK gene produces CLOCK
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Transcription of CLOCK is repressed by REV-ERBA. The promoter of CLOCK contains an RRE element that may bind REV-ERBA and RORA.

Literature References
PubMed ID Title Journal Year
10198158 Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei

Steeves, TD, King, DP, Zhao, Y, Sangoram, AM, Du, F, Bowcock, AM, Moore, RY, Takahashi, JS

Genomics 1999
15665827 System-level identification of transcriptional circuits underlying mammalian circadian clocks

Ueda, HR, Hayashi, S, Chen, W, Sano, M, Machida, M, Shigeyoshi, Y, Iino, M, Hashimoto, S

Nat. Genet. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
SIRT1 [nucleoplasm] (Homo sapiens)
Regulator
RAI1 [nucleoplasm] (Homo sapiens)
Summation

Inferred from mouse homologs, RAI1 increases transcription of the CLOCK gene (Williams et al. 2012).

Inferred From
Expression of Clock (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Somers, J  (2021-01-23)
Created
May, B  (2011-06-30)
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