Expression of CLOCK

Stable Identifier
R-HSA-1368119
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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Expression of CLOCK
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The CLOCK gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Transcription of CLOCK is repressed by REV-ERBA. The promoter of CLOCK contains an RRE element that may bind REV-ERBA and RORA.

Literature References
PubMed ID Title Journal Year
10198158 Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei

Steeves, TD, King, DP, Zhao, Y, Sangoram, AM, Du, F, Bowcock, AM, Moore, RY, Takahashi, JS

Genomics 1999
15665827 System-level identification of transcriptional circuits underlying mammalian circadian clocks

Ueda, HR, Hayashi, S, Chen, W, Sano, M, Machida, M, Shigeyoshi, Y, Iino, M, Hashimoto, S

Nat. Genet. 2005
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Positively by
Inferred From
Expression of Clock (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
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