Expression of CLOCK

Stable Identifier
R-HSA-1368119
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Synonyms
CLOCK gene produces CLOCK
ReviewStatus
5/5
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Expression of CLOCK
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The CLOCK gene is transcribed to yield mRNA and the mRNA is translated to yield CLOCK protein (Steeves et al. 1999, Ueda et al. 2005, also inferred from mouse homologs). Transcription of CLOCK is repressed by REV-ERBA. The promoter of CLOCK contains an RRE element that may bind REV-ERBA and RORA. Inferred from mouse homologs, RAI1 increases transcription of the CLOCK gene (Williams et al. 2012).
Literature References
PubMed ID Title Journal Year
15665827 System-level identification of transcriptional circuits underlying mammalian circadian clocks

Hayashi, S, Hashimoto, S, Iino, M, Chen, W, Machida, M, Shigeyoshi, Y, Ueda, HR, Sano, M

Nat. Genet. 2005
10198158 Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei

Bowcock, AM, Zhao, Y, Sangoram, AM, Moore, RY, King, DP, Du, F, Takahashi, JS, Steeves, TD

Genomics 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
SIRT1 [nucleoplasm] (Homo sapiens)
Regulator
RAI1 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Clock (Mus musculus)
Authored
May, B  (2011-06-22)
Reviewed
Somers, J  (2021-01-23)
Delaunay, F  (2012-01-28)
Created
May, B  (2011-06-30)
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