Reactome | CDH1 binds to PIP5K1C

CDH1 binds to PIP5K1C

Stable Identifier

R-HSA-9935209

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

3/5

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 posttranslational processing and trafficking to plasma membrane (Homo sapiens)
        
        CDH1 binds to PIP5K1C (Homo sapiens)

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PIP5K1C (also known as PIPKIgamma or Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma), an enzyme initially implicated in the regulation of focal adhesions (Ling et al. 2002), was shown to be involved in trafficking of CDH1 (E-cadherin) to the plasma membrane and regulation of adherens junctions (Ling et al. 2007). Endogenous human PIP5K1C and CDH1 were shown to bind and co-localize in human breast carcinoma cell lines (Ling et al. 2007). Experiments with recombinant mouse PIP5K1C and recombinant human CDH1 have shown that PIP5K1C binds to the C-terminus of CDH1 (Ling et al. 2007). O-glycosylation of the C-terminus of CDH1 during apoptosis prevents PIP5K1C binding (Geng et al. 2012). Binding of CDH1 to catenins does not affect PIP5K1C binding (Ling et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17261850	Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin Ling, K, Bairstow, SF, Carbonara, C, Turbin, DA, Huntsman, DG, Anderson, RA	J Cell Biol	2007
22375065	Multiple post-translational modifications regulate E-cadherin transport during apoptosis Geng, F, Zhu, W, Anderson, RA, Leber, B, Andrews, DW	J Cell Sci	2012