Reactome | sktl [cytosol]

sktl [cytosol]

Stable Identifier

R-DME-392427-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

PIP5K1C, Q9W2R3

Locations in the PathwayBrowser

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Developmental Biology (Drosophila melanogaster)

- Nervous system development (Drosophila melanogaster)
  - Axon guidance (Drosophila melanogaster)
    - Semaphorin interactions (Drosophila melanogaster)
      - SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Drosophila melanogaster)
        
        Inhibition of integrin activation by sequestering PIP5KIgamma (Drosophila melanogaster)
        
        FARP2:PIP5KIgamma [cytosol] (Drosophila melanogaster)
        
        Homologues of PIP5K1C [cytosol] (Drosophila melanogaster)
        
        sktl [cytosol] (Drosophila melanogaster)
        
        PIP5K1gamma:Talin-1 [cytosol] (Drosophila melanogaster)
        
        Homologues of PIP5K1C [cytosol] (Drosophila melanogaster)
        
        sktl [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - PIP3 activates AKT signaling (Drosophila melanogaster)
    - Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
        
        PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)
        
        PIP5K1A-C [cytosol] (Drosophila melanogaster)
        
        Homologues of PIP5K1C [cytosol] (Drosophila melanogaster)
        
        sktl [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W2R3

Gene Names

sktl

Reference Genes

BioGPS Gene:37356 sktl

ENSEMBL:FBgn0016984

FlyBase:FBgn0016984

KEGG:dme:Dmel_CG9985 sktl

Monarch:37356 sktl

NCBI Gene:37356 sktl

UCSC:Q9W2R3 sktl

Reference Transcript

Other Identifiers

141344_at

1624275_at

37356

GO:0001837

GO:0003383

GO:0005634

GO:0005694

GO:0005737

GO:0005886

GO:0005929

GO:0005938

GO:0006629

GO:0007010

GO:0007032

GO:0007163

GO:0007283

GO:0007286

GO:0007310

GO:0007444

GO:0008103

GO:0008104

GO:0016020

GO:0016301

GO:0016308

GO:0016324

GO:0016740

GO:0022414

GO:0030154

GO:0030198

GO:0030707

GO:0030866

GO:0031514

GO:0035323

GO:0042995

GO:0043226

GO:0046488

GO:0046843

GO:0046854

GO:0048477

GO:0048856

GO:0052742

GO:0071711

GO:0071963

GO:1903689

Participates

as a member of

Homologues of PIP5K1C [cytosol] (Drosophila melanogaster)

Other forms of this molecule

sktl [cytosol]

Inferred From

PIP5K1C [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001286647.1, NP_001286646.1, NP_477206.1

ENSEMBL

FBtr0071563, FBpp0309638, FBtr0342801, FBgn0016984, FBtr0344196, FBpp0071491, FBpp0310605

FlyBase

FBgn0016984