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CRK, CRKL [cytosol]
Stable Identifier
R-HSA-381945
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL binds CRK (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
p(Y700,731,774)-CBL:CRK [cytosol] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
CBL:CRKL binds RAPGEF1 (Homo sapiens)
p(Y700,731,774)-CBL:CRK [cytosol] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Homo sapiens)
p(Y700,731,774)-CBL:CRK [cytosol] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates RAP1 and RAC1 (Homo sapiens)
CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
DOCK7 activates RAC1 (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
GAB1 recruits CRK,CRKL to MET (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
RAPGEF1 activates RAP1 (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
RAPGEF1 binds CRK,CRKL (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
MET receptor recycling (Homo sapiens)
GGA3 associates with activated MET receptor (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
CRK, CRKL [cytosol] (Homo sapiens)
Participants
members
CRKL [cytosol]
(Homo sapiens)
CRK [cytosol]
(Homo sapiens)
Participates
as a component of
p(Y700,731,774)-CBL:CRK [cytosol] (Homo sapiens)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
as an input of
CBL binds CRK (Homo sapiens)
GAB1 recruits CRK,CRKL to MET (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
Inferred To
ced-2 [cytosol]
(Caenorhabditis elegans)
CRK [cytosol]
(Gallus gallus)
Crk [cytosol]
(Drosophila melanogaster)
CRK, CRKL [cytosol]
(Bos taurus)
CRK, CRKL [cytosol]
(Canis familiaris)
CRK, CRKL [cytosol]
(Danio rerio)
CRK, CRKL [cytosol]
(Mus musculus)
CRK, CRKL [cytosol]
(Rattus norvegicus)
CRK, CRKL [cytosol]
(Sus scrofa)
crk [cytosol]
(Xenopus tropicalis)
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