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CRK [cytosol]
Stable Identifier
R-GGA-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
CRK, Q04929
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
Regulation of signaling by CBL (Gallus gallus)
CBL binds CRK (Gallus gallus)
CRK [cytosol] (Gallus gallus)
p(Y700,731,774)-CBL:CRK [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CBL:CRKL binds RAPGEF1 (Gallus gallus)
p(Y700,731,774)-CBL:CRK [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Gallus gallus)
p(Y700,731,774)-CBL:CRK [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signaling by Non-Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PTK6 (Gallus gallus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Gallus gallus)
Activation of RAC1 by the PXN:CRK complex (Gallus gallus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Phosphorylated PXN recruits the CRK complex (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by MET (Gallus gallus)
MET promotes cell motility (Gallus gallus)
MET activates RAP1 and RAC1 (Gallus gallus)
CRK,CRKL recruits RAC1 GEF to activated MET (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
DOCK7 activates RAC1 (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
GAB1 recruits CRK,CRKL to MET (Gallus gallus)
CRK [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
RAPGEF1 activates RAP1 (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
RAPGEF1 binds CRK,CRKL (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
MET receptor recycling (Gallus gallus)
GGA3 associates with activated MET receptor (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK1 (TRKA) (Gallus gallus)
Signalling to ERKs (Gallus gallus)
Prolonged ERK activation events (Gallus gallus)
ARMS-mediated activation (Gallus gallus)
ARMS is phosphorylated by active TrkA receptor (Gallus gallus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Gallus gallus)
ARMS:Crk [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Gallus gallus)
Phospho-ARMS:Crk [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Gallus gallus)
Phospho-ARMS:Crk [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Crk's SH3 domain engages C3G (Gallus gallus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Gallus gallus)
Phospho-ARMS:Crk [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
Crk binds to the active PDGF receptor (Gallus gallus)
CRK [cytosol] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
CRK binds BCAR1 and or PXN (Gallus gallus)
CRK [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
DOCK180:ELMO binds CRK (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
CRK [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q04929
Gene Names
CRK
Reference Genes
BioGPS Gene:107054794 CRK
ENSEMBL:ENSGALG00000002656
Monarch:107054794 CRK
NCBI Gene:107054794 CRK
UCSC:Q04929 CRK
Reference Transcript
RefSeq:NM_001007846.1 CRK
RefSeq:NM_001353939.2 CRK
RefSeq:XM_015296031.1 CRK
Other Identifiers
107054794
GO:0001784
GO:0005515
GO:0005737
GO:0005886
GO:0007010
GO:0007167
GO:0008360
GO:0009966
GO:0016020
GO:0016477
GO:0017124
GO:0019900
GO:0030036
GO:0030971
GO:0032956
GO:0032991
GO:0035591
GO:0042169
GO:0043087
GO:0045309
GO:0046875
GO:0048013
GO:0048870
GO:0060090
GO:0061045
GO:1900026
GO:1902531
GO:1990782
GO:2000145
GO:2000146
GT_A_87_P133648
GT_A_87_P140518
GT_Sp_Chicken_CO761992_7624
Gga.1932.1.S1_at
Participates
as an input of
Crk binding to p130cas (Gallus gallus)
GAB1 recruits CRK,CRKL to MET (Gallus gallus)
Crk binds to the active PDGF receptor (Gallus gallus)
CBL binds CRK (Gallus gallus)
CRK binds BCAR1 and or PXN (Gallus gallus)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Gallus gallus)
p(Y700,731,774)-CBL:CRK [cytosol] (Gallus gallus)
Phospho-ARMS:Crk [cytosol] (Gallus gallus)
ARMS:Crk [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Gallus gallus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
Inferred From
CRK, CRKL [cytosol]
(Homo sapiens)
CRK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001340868.1
,
NP_001007847.1
,
XP_015151517.1
ENSEMBL
ENSGALT00010070926
,
ENSGALP00010043617
,
ENSGALG00010029327
PRO
Q04929
PDB
2L3Q
,
2L3S
,
2L3P
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