Reactome | GAB1 recruits CRK,CRKL to MET

GAB1 recruits CRK,CRKL to MET

Stable Identifier

R-HSA-8875540

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Splicing isoforms of adapter protein CRK, CRK-1 (CRKI) and CRK-2 (CRKII), as well as the related adapter protein CRKL can be recruited to the activated MET receptor via association with tyrosine phosphorylated GAB1 (Garcia-Guzman et al. 1999, Schaeper et al. 2000, Sakkab et al. 2000, Lamorte et al. 2000, Lamorte et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses Kempkes, B, Fuchs, KP, Birchmeier, W, Sachs, M, Gehring, NH, Schaeper, U	J. Cell Biol.	2000
10618718	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation Zeh, K, Dolfi, F, Vuori, K, Garcia-Guzman, M	Oncogene	1999
11146548	A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein Park, M, Lamorte, L, Kamikura, DM	Oncogene	2000
12138161	Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program Lamorte, L, Naujokas, M, Park, M, Rodrigues, S	J. Biol. Chem.	2002
10753869	Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL Lewitzky, M, Sakkab, D, Posern, G, Feller, SM, Birchmeier, W, Sachs, M, Schaeper, U	J. Biol. Chem.	2000