Reactome | CBL binds CRK

CBL binds CRK

Stable Identifier

R-HSA-912790

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The Crk adapter protein family is comprised of Crk-I and Crk-II, alternatively spliced products of a single gene with differing biological functions, and Crk-L, a distinct Crk-like gene product. Cbl is the dominant phosphoprotein associated with Crk in activated lymphocytes. In vitro binding indicates that the Crk SH2 domain binds Y774 of Cbl (Reedquist et al. 1996), leaving the SH3 domain of Crk free to interact with other SH3 domain-associated proteins.

Literature References

PubMed ID	Title	Journal	Year
8626543	Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G Reedquist, KA, Fukazawa, T, Panchamoorthy, G, Langdon, WY, Shoelson, SE, Druker, BJ, Band, H	J Biol Chem	1996
8649859	The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain Andoniou, CE, Thien, CB, Langdon, WY	Oncogene	1996