p-S724-ERN1 [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-381029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
IRE1 (phosphorylated)
Locations in the PathwayBrowser
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General
IRE1 is trans-autophosphorylated after dissociation from BiP and autodimerization. By homology with the yeast IRE1, human IRE1 is believed to be phosphorylated at Ser724 (Ser841 of Saccharomyces cerevisiae)
Literature References
PubMed ID Title Journal Year
16973740 The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

Back, SH, Liu, CY, Kaufman, RJ, Peisach, D, Zhou, J, Xu, Z, Clark, RL

Proc Natl Acad Sci U S A 2006
11069889 The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

Lee, K, Kaufman, RJ, Callaghan, B, Welihinda, A, Tirasophon, W

Genes Dev 2000
9637683 A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

Kaufman, RJ, Welihinda, AA, Tirasophon, W

Genes Dev 1998
External Reference Information
External Reference
UniProt:O75460 ERN1
Gene Names
ERN1, IRE1
Chain
signal peptide:1-18, chain:19-977
Reference Genes
COSMIC (genes):ERN1 ERN1
dbSNP Gene:2081 ERN1
ENSEMBL:ENSG00000178607 ERN1
Participates
as a component of
Other forms of this molecule
ERN1 [endoplasmic reticulum membrane]
Inferred To
phospho-Ire1 [endoplasmic reticulum membrane] (Drosophila melanogaster)
phospho-ern2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
phospho-ERN1 [endoplasmic reticulum membrane] (Bos taurus)
phospho-ERN1 [endoplasmic reticulum membrane] (Canis familiaris)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Gallus gallus)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Mus musculus)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
phospho-Ern1 [endoplasmic reticulum membrane] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 724
Coordinate
724
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (8)
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