p-S724-ERN1 [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-381029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
IRE1 (phosphorylated)
Locations in the PathwayBrowser
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General

IRE1 is trans-autophosphorylated after dissociation from BiP and autodimerization. By homology with the yeast IRE1, human IRE1 is believed to be phosphorylated at Ser724 (Ser841 of Saccharomyces cerevisiae)

Literature References
PubMed ID Title Journal Year
16973740 The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

Back, SH, Liu, CY, Kaufman, RJ, Peisach, D, Zhou, J, Xu, Z, Clark, RL

Proc Natl Acad Sci U S A 2006
11069889 The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

Lee, K, Kaufman, RJ, Callaghan, B, Welihinda, A, Tirasophon, W

Genes Dev 2000
9637683 A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

Kaufman, RJ, Welihinda, AA, Tirasophon, W

Genes Dev 1998
External Reference Information
External Reference
UniProt:O75460 ERN1
Gene Names
ERN1, IRE1
Chain
signal peptide:1-18, chain:19-977
Reference Genes
BioGPS Gene:2081 ERN1
COSMIC (genes):ERN1 ERN1
CTD Gene:2081 ERN1
dbSNP Gene:2081 ERN1
ENSEMBL:ENSG00000178607 ERN1
ENSEMBL:ENSG00000178607.17 ERN1
HGNC:3449 ERN1
KEGG Gene (Homo sapiens):2081 ERN1
Monarch:2081 ERN1
NCBI Gene:2081 ERN1
OMIM:604033 ERN1
UCSC:O75460 ERN1
Reference Transcript
Other Identifiers
11741334_at
11741335_at
16847771
207061_PM_at
207061_at
2081
227755_PM_at
227755_at
235745_PM_at
235745_at
239045_PM_at
239045_at
31380_at
3766646
3766648
3766650
3766652
3766653
3766654
3766655
3766656
3766657
3766658
3766659
3766660
3766661
3766663
3766664
3766665
3766666
3766668
3766669
3766670
3766673
3766677
3766678
3766679
3766680
3766682
3766683
3766686
3766688
3766689
3766694
3766700
3766701
3766702
3766703
3766704
3766705
3766706
3766707
3766709
3766711
3766712
3766713
3766715
60109_at
69557_g_at
76574_at
8017555
87738_at
91417_at
A_23_P164042
A_23_P436259
A_24_P296689
A_24_P322313
GE489312
GE739453
GE739853
GE794909
GO:0000166
GO:0000287
GO:0001935
GO:0003824
GO:0004519
GO:0004521
GO:0004540
GO:0004672
GO:0004674
GO:0005161
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005637
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006397
GO:0006402
GO:0006468
GO:0006914
GO:0006915
GO:0006986
GO:0008152
GO:0010468
GO:0012501
GO:0016020
GO:0016071
GO:0016241
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0019899
GO:0023052
GO:0030544
GO:0030968
GO:0033120
GO:0034620
GO:0034976
GO:0035924
GO:0036211
GO:0036289
GO:0036498
GO:0042802
GO:0042803
GO:0043226
GO:0043507
GO:0043531
GO:0046777
GO:0046872
GO:0051082
GO:0051252
GO:0051879
GO:0070054
GO:0070059
GO:0070301
GO:0071333
GO:0090502
GO:0106310
GO:0140096
GO:0140098
GO:1900103
GO:1901142
GO:1904707
GO:1990332
GO:1990579
GO:1990597
GO:1990604
GO:1990630
HMNXSV003006784
HMNXSV003048975
HMNXSV003051469
Hs.129166.0.A1_3p_at
Hs.184108.2.S1_3p_at
Hs.30778.0.A1_3p_at
ILMN_1698404
ILMN_1731231
PH_hs_0007520
PH_hs_0017286
PH_hs_0031687
TC17001795.hg
TC17001796.hg
TC17002746.hg
g4557568_3p_at
p6982
Participates
as a component of
Other forms of this molecule
ERN1 [endoplasmic reticulum membrane]
Inferred To
phospho-ern1 [endoplasmic reticulum membrane] (Xenopus tropicalis)
phospho-Ire1 [endoplasmic reticulum membrane] (Drosophila melanogaster)
phospho-ERN1 [endoplasmic reticulum membrane] (Bos taurus)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Canis familiaris)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Danio rerio)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Gallus gallus)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Mus musculus)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)
phospho-p-S724-ERN1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)
phospho-Ern1 [endoplasmic reticulum membrane] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 724
Coordinate
724
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
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HMDB Protein
Interactors (6)
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