p-S724-ERN1 [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-381029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
IRE1 (phosphorylated)
Locations in the PathwayBrowser
General

IRE1 is trans-autophosphorylated after dissociation from BiP and autodimerization. By homology with the yeast IRE1, human IRE1 is believed to be phosphorylated at Ser724 (Ser841 of Saccharomyces cerevisiae)

Literature References
PubMed ID Title Journal Year
11069889 The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

Tirasophon, W, Lee, K, Callaghan, B, Welihinda, A, Kaufman, RJ

Genes Dev 2000
16973740 The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

Zhou, J, Liu, CY, Back, SH, Clark, RL, Peisach, D, Xu, Z, Kaufman, RJ

Proc Natl Acad Sci U S A 2006
9637683 A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

Tirasophon, W, Welihinda, AA, Kaufman, RJ

Genes Dev 1998
External Reference Information
External Reference
Gene Names
ERN1, IRE1
Chain
signal peptide:1-18, chain:19-977
Reference Transcript
Other Identifiers
0002370079
0003940609
0101190563
04150+2.7.11.1
04151+2.7.11.1
04714+2.7.11.1
04926+2.7.11.1
05163+2.7.11.1
05165+2.7.11.1
05170+2.7.11.1
11741334_at
11741335_at
16847771
207061_at
2081
227755_at
235745_at
27730
2HZ6
31380_at
3766652
3766653
3766654
3766655
3766656
3766657
3766658
3766659
3766660
3766661
3766663
3766664
3766665
3766666
3766668
3766669
3766670
3766673
3766677
3766678
3766679
3766680
3766682
3766683
3766686
3766688
3766689
3766694
3766702
3766703
3766704
3766705
3766706
3766707
3P23
4U6R
4YZ9
4YZC
4YZD
4Z7G
4Z7H
5HGI
69557_g_at
76574_at
8017555
9495
A_23_P164042
A_23_P436259
A_24_P296689
A_24_P322313
AAC25991
AAI30406
AAI30408
AB209869
AC005803
AC025362
AF059198
AK292403
BAD93106
BAF85092
BC130405
BC130407
BI912495
CAB009495
CCDS45762
CH471109
DA254477
EAW94214
ENSG00000178607
ENSP00000401445
ENSP00000475519
ENST00000433197
ENST00000433197.3
ENST00000606895
ENST00000606895.1
EntrezGene:2081
ERN1
ERN1-201
ERN1-208
g4557568_3p_at
GE739453
GE794909
GO:0000166
GO:0000287
GO:0001935
GO:0003674
GO:0003824
GO:0004518
GO:0004519
GO:0004521
GO:0004540
GO:0004672
GO:0004674
GO:0005161
GO:0005515
GO:0005524
GO:0005575
GO:0005637
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006379
GO:0006397
GO:0006402
GO:0006464
GO:0006468
GO:0006915
GO:0006950
GO:0006986
GO:0007050
GO:0007165
GO:0007257
GO:0008150
GO:0008152
GO:0008219
GO:0008283
GO:0009056
GO:0016020
GO:0016021
GO:0016241
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0019899
GO:0030176
GO:0030544
GO:0030968
GO:0032991
GO:0033120
GO:0034620
GO:0034641
GO:0034655
GO:0034976
GO:0035924
GO:0036289
GO:0036498
GO:0042592
GO:0042802
GO:0042803
GO:0043167
GO:0043226
GO:0043531
GO:0046777
GO:0046872
GO:0051082
GO:0051879
GO:0070054
GO:0070059
GO:0071333
GO:0090502
GO:0098787
GO:1900103
GO:1901142
GO:1904707
GO:1990332
GO:1990579
GO:1990597
GO:1990604
GO:1990630
HGNC:3449
HPA027730
Hs.129166.0.A1_3p_at
Hs.184108.2.S1_3p_at
ILMN_1692064
ILMN_1698404
ILMN_1731231
IPR000719
IPR008271
IPR010513
IPR011009
IPR011047
IPR015943
IPR018391
IPR018997
IPR038357
MIM:604033
NM_001433
NP_001424
PF00069
PF06479
PH_hs_0007520
PH_hs_0017286
PH_hs_0031687
SM00220
SM00564
SM00580
TC17001795.hg
TC17001796.hg
TC17002746.hg
UPI0000201263
UPI00003CEFBC
XM_017024347
XM_017024348
XP_016879836
XP_016879837
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 724
Coordinate
724
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
GeneCards
ZINC - Substances
ZINC target
PRO
ZINC - Predictions - Purchasable
HMDB Protein