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ERN1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-381076
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
IRE1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
IRE1 binds IRE1 forming dimer (Homo sapiens)
ERN1 [endoplasmic reticulum membrane] (Homo sapiens)
IRE1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ERN1 [endoplasmic reticulum membrane] (Homo sapiens)
IRE1 dimer autophosphorylates (Homo sapiens)
IRE1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
ERN1 [endoplasmic reticulum membrane] (Homo sapiens)
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
ERN1 [endoplasmic reticulum membrane] (Homo sapiens)
IRE1:BiP [endoplasmic reticulum membrane] (Homo sapiens)
ERN1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75460 ERN1
Gene Names
ERN1, IRE1
Chain
signal peptide:1-18, chain:19-977
Reference Genes
BioGPS Gene:2081 ERN1
COSMIC (genes):ERN1 ERN1
CTD Gene:2081 ERN1
dbSNP Gene:2081 ERN1
ENSEMBL:ENSG00000178607 ERN1
ENSEMBL:ENSG00000178607.17 ERN1
HGNC:3449 ERN1
KEGG Gene (Homo sapiens):2081 ERN1
Monarch:2081 ERN1
NCBI Gene:2081 ERN1
OMIM:604033 ERN1
UCSC:O75460 ERN1
Reference Transcript
RefSeq:NM_001433.3 ERN1
Other Identifiers
11741334_at
11741335_at
16847771
207061_PM_at
207061_at
2081
227755_PM_at
227755_at
235745_PM_at
235745_at
239045_PM_at
239045_at
31380_at
3766646
3766648
3766650
3766652
3766653
3766654
3766655
3766656
3766657
3766658
3766659
3766660
3766661
3766663
3766664
3766665
3766666
3766668
3766669
3766670
3766673
3766677
3766678
3766679
3766680
3766682
3766683
3766686
3766688
3766689
3766694
3766700
3766701
3766702
3766703
3766704
3766705
3766706
3766707
3766709
3766711
3766712
3766713
3766715
60109_at
69557_g_at
76574_at
8017555
87738_at
91417_at
A_23_P164042
A_23_P436259
A_24_P296689
A_24_P322313
GE489312
GE739453
GE739853
GE794909
GO:0000166
GO:0000287
GO:0001935
GO:0003824
GO:0004519
GO:0004521
GO:0004540
GO:0004672
GO:0004674
GO:0005161
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005637
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006397
GO:0006402
GO:0006468
GO:0006914
GO:0006915
GO:0006986
GO:0008152
GO:0010468
GO:0012501
GO:0016020
GO:0016071
GO:0016241
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0019899
GO:0023052
GO:0030544
GO:0030968
GO:0033120
GO:0034620
GO:0034976
GO:0035924
GO:0036211
GO:0036289
GO:0036498
GO:0042802
GO:0042803
GO:0043226
GO:0043507
GO:0043531
GO:0046777
GO:0046872
GO:0051082
GO:0051252
GO:0051879
GO:0070054
GO:0070059
GO:0070301
GO:0071333
GO:0090502
GO:0106310
GO:0140096
GO:0140098
GO:1900103
GO:1901142
GO:1904707
GO:1990332
GO:1990579
GO:1990597
GO:1990604
GO:1990630
HMNXSV003006784
HMNXSV003048975
HMNXSV003051469
Hs.129166.0.A1_3p_at
Hs.184108.2.S1_3p_at
Hs.30778.0.A1_3p_at
ILMN_1698404
ILMN_1731231
PH_hs_0007520
PH_hs_0017286
PH_hs_0031687
TC17001795.hg
TC17001796.hg
TC17002746.hg
g4557568_3p_at
p6982
Participates
as an output of
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
as a component of
IRE1:BiP [endoplasmic reticulum membrane] (Homo sapiens)
IRE1 dimer [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
IRE1 binds IRE1 forming dimer (Homo sapiens)
Other forms of this molecule
p-S724-ERN1 [endoplasmic reticulum membrane]
Inferred To
ern1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Ire1 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Ern1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
ERN1 [endoplasmic reticulum membrane]
(Bos taurus)
ERN1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
ERN1 [endoplasmic reticulum membrane]
(Canis familiaris)
ERN1 [endoplasmic reticulum membrane]
(Danio rerio)
ERN1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
ERN1 [endoplasmic reticulum membrane]
(Gallus gallus)
ERN1 [endoplasmic reticulum membrane]
(Mus musculus)
ERN1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
ERN1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001424.3
ZINC - World Drugs
ERN1_HUMAN
Guide to Pharmacology - Targets
2020
OpenTargets
ENSG00000178607
ZINC - FDA approved
ERN1_HUMAN
ZINC - Substances
ERN1_HUMAN
ZINC target
O75460
ZINC - Biogenic
ERN1_HUMAN
PRO
O75460
PDB
2HZ6
,
6W3C
,
7BMK
,
6HV0
,
3P23
,
6XDB
,
5HGI
,
6XDF
,
4YZ9
,
4Z7G
,
6W3B
,
6W3E
,
6W39
,
4YZC
,
6URC
,
4Z7H
,
6SHC
,
4U6R
,
6HX1
,
6XDD
,
4YZD
,
6W3K
,
6W3A
ZINC - Investigational
ERN1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000178607-ERN1
GeneCards
O75460
Ensembl
ENST00000433197
,
ENSP00000475519
,
ENST00000606895
,
ENSG00000178607
,
ENSP00000401445
Pharos - Targets
O75460
ZINC - Predictions - Purchasable
ERN1_HUMAN
HMDB Protein
HMDBP08718
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.628
3
UniProt:O75460 ERN1
2
p-S724-ERN1 [endoplasmic reticulum membrane]
(R-HSA-381029)
ERN1 [endoplasmic reticulum membrane]
(R-HSA-381076)
0.609
2
UniProt:Q969M3 YIPF5
0.537
3
UniProt:Q86TM6 SYVN1
1
SYVN1(1-617) [endoplasmic reticulum membrane]
(R-HSA-535496)
0.524
2
UniProt:Q07813
2
Bax [cytosol]
(R-MMU-139907)
Bax [mitochondrial outer membrane]
(R-MMU-139949)
0.524
2
UniProt:Q9H2K8 TAOK3
1
TAOK3 [cytosol]
(R-HSA-5423594)
0.508
3
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