Reactome | p-S724-IRE1 dimer [endoplasmic reticulum membrane]

p-S724-IRE1 dimer [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-381154

Type

Complex

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

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General

After juxtaposition of the luminal N-termini of IRE1 to form the IRE1 homodimer, the cytoplasmic C-terminal kinase domains of the IRE1 molecules associate and transphosphorylate each other's A-loop domains. This causes a change in conformation that allows binding of ADP.

Literature References

PubMed ID	Title	Journal	Year
16973740	The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response Zhou, J, Liu, CY, Back, SH, Clark, RL, Peisach, D, Xu, Z, Kaufman, RJ	Proc Natl Acad Sci U S A	2006
11069889	The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response Tirasophon, W, Lee, K, Callaghan, B, Welihinda, A, Kaufman, RJ	Genes Dev	2000
9637683	A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells Tirasophon, W, Welihinda, AA, Kaufman, RJ	Genes Dev	1998