Enzymatic degradation of dopamine by COMT

Stable Identifier
R-HSA-379397
Type
Pathway
Species
Homo sapiens
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Enzymatic degradation of dopamine by COMT
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Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.

Literature References
PubMed ID Title Journal Year
17185601 Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure

Nackley, AG, Shabalina, SA, Tchivileva, IE, Satterfield, K, Korchynskyi, O, Makarov, SS, Maixner, W, Diatchenko, L

Science 2006
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Orthologous Events
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Enzymatic degradation of dopamine by COMT (Drosophila melanogaster)
Enzymatic degradation of dopamine by COMT (Gallus gallus)
Enzymatic degradation of dopamine by COMT (Mus musculus)
Enzymatic degradation of dopamine by COMT (Plasmodium falciparum)
Enzymatic degradation of dopamine by COMT (Rattus norvegicus)
Enzymatic degradation of dopamine by COMT (Schizosaccharomyces pombe)
Enzymatic degradation of dopamine by COMT (Sus scrofa)
Enzymatic degradation of dopamine by COMT (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Mahajan, SS  (2008-08-06)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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