Enzymatic degradation of dopamine by COMT

Stable Identifier
R-HSA-379397
Type
Pathway
Species
Homo sapiens
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Dopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catecholamine o-methyl transferase and the subsequent reaction is catalyzed by monoamine oxidase A.

Literature References
PubMed ID Title Journal Year
17185601 Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure

Nackley, AG, Shabalina, SA, Tchivileva, IE, Satterfield, K, Korchynskyi, O, Makarov, SS, Maixner, W, Diatchenko, L

Science 2006
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