COMT binds COMT Inhibitors

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine) and various substances having a catechol structure. COMT inhibitors such as entacapone, tolcapone and opicapone are used in the treatment of Parkinson's disease.

Literature References
PubMed ID Title Journal Year
24847974 A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT)

Lanier, M, Ambrus, G, Cole, DC, Davenport, R, Ellery, J, Fosbeary, R, Jennings, AJ, Kadotani, A, Kamada, Y, Kamran, R, Matsumoto, S, Mizukami, A, Okubo, S, Okada, K, Saikatendu, K, Walsh, L, Wu, H, Hixon, MS

J. Med. Chem. 2014
7703232 Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

Lotta, T, Vidgren, J, Tilgmann, C, Ulmanen, I, Melén, K, Julkunen, I, Taskinen, J

Biochemistry 1995
Participant Of
Orthologous Events
Cite Us!