Reactome | LRTOMT transfers Met to DA, forming 3MT

LRTOMT transfers Met to DA, forming 3MT

Stable Identifier

R-HSA-8955010

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalyses the O-methylation of catecholamine neurotransmitters, thereby inactivating them (Du et al. 2008). LRTOMT is highly expressed in sensory hair cells of the inner ear. Defects in LRTOMT can cause autosomal recessive deafness 63 (DFNB63), a form of non-syndromic sensorineural hearing loss (Ahmed et al. 2008, Du et al. 2008). In this example, dopamine (DA) is O-methylated using S-adenosyl-L-methionine (AdoMet) as the methyl donor to form 3-methyltyramine (3MT) and S-adenosyl-L-homocysteine (AdoHcy).

Literature References

PubMed ID	Title	Journal	Year
18794526	A catechol-O-methyltransferase that is essential for auditory function in mice and humans Beutler, B, Smith, RJ, Roberts, A, Koob, G, Schwander, M, Moresco, EM, Müller, U, Viviani, P, Tarantino, L, Hildebrand, MS, Ryan, AF, Du, X, Najmabadi, H, Richardson, H, Haller, C, Pak, K	Proc. Natl. Acad. Sci. U.S.A.	2008
18953341	Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans Ayadi, H, Charfedine, I, Masmoudi, S, Collin, RW, Oostrik, J, Friedman, TB, Kawar, MN, Griffith, AJ, Kremer, H, Tlili, A, Morell, RJ, Hmani-Aifa, M, Karaguzel, A, Riazuddin, S, Khan, SY, Venselaar, H, Riazuddin, SA, Belyantseva, IA, Mosrati, MA, Caylan, R, Kalay, E, Ahmed, ZM, van der Zwaag, B, Ghorbel, A, Riazuddin, S, Ayadi, L	Nat. Genet.	2008