LRTOMT transfers methyl group from AdoMet to DA, forming 3MT

Stable Identifier
R-HSA-8955010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Transmembrane O-methyltransferase (LRTOMT aka COMT2) catalyses the O-methylation of catecholamine neurotransmitters, thereby inactivating them (Du et al. 2008). LRTOMT is highly expressed in sensory hair cells of the inner ear. Defects in LRTOMT can cause autosomal recessive deafness 63 (DFNB63), a form of non-syndromic sensorineural hearing loss (Ahmed et al. 2008, Du et al. 2008). In this example, dopamine (DA) is O-methylated using S-adenosyl-L-methionine (AdoMet) as the methyl donor to form 3-methyltyramine (3MT) and S-adenosyl-L-homocysteine (AdoHcy).

Literature References
PubMed ID Title Journal Year
18953341 Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans

Ahmed, ZM, Masmoudi, S, Kalay, E, Belyantseva, IA, Mosrati, MA, Collin, RW, Riazuddin, S, Hmani-Aifa, M, Venselaar, H, Kawar, MN, Tlili, A, van der Zwaag, B, Khan, SY, Ayadi, L, Riazuddin, SA, Morell, RJ, Griffith, AJ, Charfedine, I, Caylan, R, Oostrik, J, Karaguzel, A, Ghorbel, A, Riazuddin, S, Friedman, TB, Ayadi, H, Kremer, H

Nat. Genet. 2008
18794526 A catechol-O-methyltransferase that is essential for auditory function in mice and humans

Du, X, Schwander, M, Moresco, EM, Viviani, P, Haller, C, Hildebrand, MS, Pak, K, Tarantino, L, Roberts, A, Richardson, H, Koob, G, Najmabadi, H, Ryan, AF, Smith, RJ, Müller, U, Beutler, B

Proc. Natl. Acad. Sci. U.S.A. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
catechol O-methyltransferase activity of LRTOMT [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created