COMT transfers Met to DA to form 3MT

Stable Identifier
R-HSA-379387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
methylation of Dopamine to form 3-Methoxytyramine
Locations in the PathwayBrowser
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Dopamine (DA) in the cytosol is methylated to 3-methoxytyramine (3MT) by catecholamine O-methyltransferase (COMT), which uses s-adenosylmethionine (AdoMet) as a methyl group donor (Männistö & Kaakkola 1991, Westerink & Spaan 1989).

Literature References
PubMed ID Title Journal Year
20976142 The dopamine metabolite 3-methoxytyramine is a neuromodulator

Sotnikova, TD, Beaulieu, JM, Espinoza, S, Masri, B, Zhang, X, Salahpour, A, Barak, LS, Caron, MG, Gainetdinov, RR

PLoS ONE 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of COMT [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created
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