methylation of Dopamine to form 3-Methoxytyramine

Stable Identifier
R-HSA-379387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dopamine (DA) in the cytosol is metabolized to 3-methoxytyramine (3MT) by catecholamine o-methyltransferase (COMT), which uses s-adenosylmethionine as a methyl group donor (Männistö and Kaakkola 1991, Westerink and Spaan 1989).

Literature References
PubMed ID Title Journal Year
20976142 The dopamine metabolite 3-methoxytyramine is a neuromodulator

Sotnikova, TD, Beaulieu, JM, Espinoza, S, Masri, B, Zhang, X, Salahpour, A, Barak, LS, Caron, MG, Gainetdinov, RR

PLoS ONE 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of COMT [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created