methylation of Dopamine to form 3-Methoxytyramine

Stable Identifier
R-HSA-379387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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methylation of Dopamine to form 3-Methoxytyramine
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Dopamine (DA) in the cytosol is metabolized to 3-methoxytyramine (3MT) by catecholamine o-methyltransferase (COMT), which uses s-adenosylmethionine as a methyl group donor (Männistö and Kaakkola 1991, Westerink and Spaan 1989).

Literature References
PubMed ID Title Journal Year
20976142 The dopamine metabolite 3-methoxytyramine is a neuromodulator

Sotnikova, TD, Beaulieu, JM, Espinoza, S, Masri, B, Zhang, X, Salahpour, A, Barak, LS, Caron, MG, Gainetdinov, RR

PLoS ONE 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
methyltransferase activity of COMT [plasma membrane]
Physical Entity
COMT [plasma membrane]
Activity
methyltransferase activity (0008168)
Orthologous Events
methylation of Dopamine to form 3-Methoxytyramine (Bos taurus)
methylation of Dopamine to form 3-Methoxytyramine (Canis familiaris)
methylation of Dopamine to form 3-Methoxytyramine (Danio rerio)
methylation of Dopamine to form 3-Methoxytyramine (Gallus gallus)
methylation of Dopamine to form 3-Methoxytyramine (Mus musculus)
methylation of Dopamine to form 3-Methoxytyramine (Rattus norvegicus)
methylation of Dopamine to form 3-Methoxytyramine (Schizosaccharomyces pombe)
methylation of Dopamine to form 3-Methoxytyramine (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-06-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)