COMT transfers Met to DA to form 3MT

Stable Identifier
R-HSA-379387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
methylation of Dopamine to form 3-Methoxytyramine
ReviewStatus
5/5
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COMT transfers Met to DA to form 3MT
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Dopamine (DA) in the cytosol is methylated to 3-methoxytyramine (3MT) by catecholamine O-methyltransferase (COMT), which uses s-adenosylmethionine (AdoMet) as a methyl group donor (Männistö & Kaakkola 1991, Westerink & Spaan 1989).
Literature References
PubMed ID Title Journal Year
20976142 The dopamine metabolite 3-methoxytyramine is a neuromodulator

Beaulieu, JM, Gainetdinov, RR, Caron, MG, Salahpour, A, Zhang, X, Barak, LS, Espinoza, S, Sotnikova, TD, Masri, B

PLoS ONE 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methyltransferase activity of COMT [plasma membrane]

Physical Entity
COMT [plasma membrane] (Homo sapiens)
Activity
methyltransferase activity (GO:0008168)
This event is regulated
Negatively by
Regulator
COMT:COMT inhibitors [plasma membrane] (Homo sapiens)
Orthologous Events
COMT transfers Met to DA to form 3MT (Bos taurus)
COMT transfers Met to DA to form 3MT (Canis familiaris)
COMT transfers Met to DA to form 3MT (Danio rerio)
COMT transfers Met to DA to form 3MT (Gallus gallus)
COMT transfers Met to DA to form 3MT (Mus musculus)
COMT transfers Met to DA to form 3MT (Rattus norvegicus)
COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)
COMT transfers Met to DA to form 3MT (Sus scrofa)
COMT transfers Met to DA to form 3MT (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2008-06-26)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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