COMT transfers Met to DA to form 3MT

Stable Identifier
R-HSA-379387
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
methylation of Dopamine to form 3-Methoxytyramine
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Dopamine (DA) in the cytosol is methylated to 3-methoxytyramine (3MT) by catecholamine O-methyltransferase (COMT), which uses s-adenosylmethionine (AdoMet) as a methyl group donor (Männistö & Kaakkola 1991, Westerink & Spaan 1989).

Literature References
PubMed ID Title Journal Year
20976142 The dopamine metabolite 3-methoxytyramine is a neuromodulator

Beaulieu, JM, Gainetdinov, RR, Caron, MG, Salahpour, A, Zhang, X, Barak, LS, Espinoza, S, Sotnikova, TD, Masri, B

PLoS ONE 2010
Participants
Participates
Catalyst Activity

methyltransferase activity of COMT [plasma membrane]

This event is regulated
Orthologous Events
Authored
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