MAOA:FAD deaminates 3MT to HVA

Stable Identifier
R-HSA-379395
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Oxidation of 3-Methoxytyramine to homovanillic acid
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3-methoxytyramine (3MT) generated by COMT after methylation of dopamine is oxidized into homovanillic acid (HVA) by monoamine oxidase A (MAOA), bound to its cofactor FAD (Guldberg et al. 1997).

Literature References
PubMed ID Title Journal Year
4398930 Some observations on the estimation of 3-methoxytyramine in brain tissue

Guldberg, HC, Sharman, DF, Tegerdine, PR

Br. J. Pharmacol. 1971
8515683 Regional homovanillic acid production in humans

Esler, MD, Jennings, GL, Lambert, GW, Eisenhofer, G

Life Sci. 1993
Participants
Participates
Catalyst Activity

primary amine oxidase activity of MAOA:FAD [mitochondrial outer membrane]

Orthologous Events
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