MAOA:FAD deaminates 3MT to HVA

Stable Identifier
R-HSA-379395
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
Synonyms
Oxidation of 3-Methoxytyramine to homovanillic acid
ReviewStatus
5/5
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MAOA:FAD deaminates 3MT to HVA
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3-methoxytyramine (3MT) generated by COMT after methylation of dopamine is oxidized into homovanillic acid (HVA) by monoamine oxidase A (MAOA), bound to its cofactor FAD (Guldberg et al. 1997).

Literature References
PubMed ID Title Journal Year
4398930 Some observations on the estimation of 3-methoxytyramine in brain tissue

Guldberg, HC, Sharman, DF, Tegerdine, PR

Br. J. Pharmacol. 1971
8515683 Regional homovanillic acid production in humans

Esler, MD, Jennings, GL, Lambert, GW, Eisenhofer, G

Life Sci. 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

primary amine oxidase activity of MAOA:FAD [mitochondrial outer membrane]

Physical Entity
MAOA:FAD [mitochondrial outer membrane] (Homo sapiens)
Activity
primary amine oxidase activity (GO:0008131)
Orthologous Events
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Danio rerio)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
MAOA:FAD deaminates 3MT to HVA (Mus musculus)
MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)
MAOA:FAD deaminates 3MT to HVA (Sus scrofa)
MAOA:FAD deaminates 3MT to HVA (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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