MAOA:FAD deaminates 3MT to HVA

Stable Identifier
R-HSA-379395
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
Synonyms
Oxidation of 3-Methoxytyramine to homovanillic acid
ReviewStatus
5/5
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MAOA:FAD deaminates 3MT to HVA
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3-methoxytyramine (3MT) generated by COMT after methylation of dopamine is oxidized into homovanillic acid (HVA) by monoamine oxidase A (MAOA), bound to its cofactor FAD (Guldberg et al. 1997).
Literature References
PubMed ID Title Journal Year
4398930 Some observations on the estimation of 3-methoxytyramine in brain tissue

Guldberg, HC, Sharman, DF, Tegerdine, PR

Br. J. Pharmacol. 1971
8515683 Regional homovanillic acid production in humans

Lambert, GW, Eisenhofer, G, Jennings, GL, Esler, MD

Life Sci. 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

primary methylamine oxidase activity of MAOA:FAD [mitochondrial outer membrane]

Physical Entity
MAOA:FAD [mitochondrial outer membrane] (Homo sapiens)
Activity
primary methylamine oxidase activity (GO:0008131)
Orthologous Events
MAOA:FAD deaminates 3MT to HVA (Bos taurus)
MAOA:FAD deaminates 3MT to HVA (Canis familiaris)
MAOA:FAD deaminates 3MT to HVA (Danio rerio)
MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)
MAOA:FAD deaminates 3MT to HVA (Gallus gallus)
MAOA:FAD deaminates 3MT to HVA (Mus musculus)
MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)
MAOA:FAD deaminates 3MT to HVA (Sus scrofa)
MAOA:FAD deaminates 3MT to HVA (Xenopus tropicalis)
Authored
Mahajan, SS  (2008-10-18)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2008-10-18)
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