Reactome | EPO [extracellular region]

EPO [extracellular region]

Stable Identifier

R-HSA-379001

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Erythropoietin, EPO_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P19235 EPOR

Expand all

External Reference Information

External Reference

UniProt:P01588 EPO

Gene Names

EPO

Chain

signal peptide:1-27, chain:28-193

Reference Genes

BioGPS Gene:2056 EPO

COSMIC - genes:EPO EPX

CTD Gene:2056 EPO

dbSNP Gene:2056 EPO

ENSEMBL:ENSG00000130427 EPO

HGNC:3415 EPO

KEGG:hsa:2056 EPO

Monarch:2056 EPO

NCBI Gene:2056 EPO

OMIM:133170 EPO

UCSC:P01588 EPO

Reference Transcript

RefSeq:NM_000799.4 EPO

Other Identifiers

1023_at

11735351_at

17049466

2056

207257_PM_at

207257_at

217254_PM_s_at

217254_s_at

3015779

3015780

3015781

3015782

3015783

3015784

3015785

3015787

8134907

A_14_P113914

A_23_P145669

GE79554

GO:0000122

GO:0001666

GO:0003013

GO:0005125

GO:0005128

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0006355

GO:0006357

GO:0006915

GO:0006950

GO:0006953

GO:0006954

GO:0007165

GO:0007566

GO:0007584

GO:0008015

GO:0008284

GO:0009651

GO:0009986

GO:0010523

GO:0010976

GO:0022414

GO:0030154

GO:0030163

GO:0030218

GO:0030295

GO:0032496

GO:0033028

GO:0033033

GO:0033189

GO:0033574

GO:0038162

GO:0042104

GO:0042541

GO:0043066

GO:0043161

GO:0043249

GO:0043627

GO:0044297

GO:0045666

GO:0045893

GO:0046579

GO:0048018

GO:0048678

GO:0051602

GO:0055093

GO:0070374

GO:0070555

GO:0071474

GO:0071548

GO:0097696

GO:0098772

GO:1902219

GO:1902251

HMNXSV003050310

Hs.2303.1.S1_3p_a_at

ILMN_1665671

PH_hs_0000310

TC07000632.hg

X02158_rna1_at

g4503588_3p_at

Participates

as a component of

as an input of

EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)

as an output of

Expression of Erythropoietin (EPO) (Homo sapiens)

Inferred To

Ghost homologue of EPO [extracellular region] (Gallus gallus)

epo [extracellular region] (Canis familiaris)

epo [extracellular region] (Danio rerio)

epo [extracellular region] (Xenopus tropicalis)

EPO [extracellular region] (Bos taurus)

EPO [extracellular region] (Sus scrofa)

Epo [extracellular region] (Mus musculus)

Epo [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000790.2

ENSEMBL

ENST00000252723, ENSG00000130427, ENSP00000252723

OpenTargets

ENSG00000130427

GeneCards

EPO

HPA

ENSG00000130427-EPO

PRO

P01588

Pharos - Targets

P01588

GlyGen

P01588

Orphanet

EPO

PDB

1EER, 1BUY, 1CN4

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19235 EPOR	2	p-8Y-EPOR [plasma membrane] (R-HSA-9006274) EPOR [plasma membrane] (R-HSA-1168347)	0.609	3
UniProt:P54760 EPHB4	6	p-Y590,Y596-EPHB4 [plasma membrane] (R-HSA-3928364) EPHB4 [plasma membrane] (R-HSA-2682323) EPHB4 (16-?) [extracellular region] (R-HSA-3928420) EPHB4 (?-987) [plasma membrane] (R-HSA-3928476) EPHB4 (?-987) [cytosol] (R-HSA-3928406) EPHB4 (?-?) [plasma membrane] (R-HSA-3928457)	0.544	6
UniProt:P33908 MAN1A1	2	MAN1A1 [transport vesicle] (R-HSA-8847488) MAN1A1 [Golgi membrane] (R-HSA-964767)	0.499	2