EPO binds EPOR:JAK2:LYN:IRS2

Stable Identifier
R-HSA-9006325
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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EPO binds EPOR:JAK2:LYN:IRS2
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Extracellular Erythropoietin (EPO) binds the EPO receptor (EPOR) located in the plasma membrane of the target cell (Jones et al. 1990, Syed et al. 1998, Remy et al. 1999, and inferred from mouse homologs). EPOR is a dimer that appears to be preassociated with downstream signaling proteins JAK2 (inferred from mouse homologs) and LYN (Chin et al. 1998, and inferred from mouse homologs) and the scaffold protein IRS2 (Verdier et al. 1997). Binding of EPO to EPOR causes a change in the conformation of the dimer which activates JAK2 (Syed et al. 1998, Remy et al. 1999, Kubatzky et al. 2001).

Literature References
PubMed ID Title Journal Year
9334184 Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2. An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation

Mayeux, P, Lacombe, C, Billat, C, Verdier, F, Gisselbrecht, S, Chrétien, S

J. Biol. Chem. 1997
9974393 Erythropoietin receptor activation by a ligand-induced conformation change

Wilson, IA, Michnick, SW, Remy, I

Science 1999
2163696 Human erythropoietin receptor: cloning, expression, and biologic characterization

D'Andrea, AD, Haines, LL, Wong, GG, Jones, SS

Blood 1990
9573010 Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway

Wakao, H, Chin, H, Kamiyama, R, Arai, A, Miura, O, Miyasaka, N

Blood 1998
9774108 Efficiency of signalling through cytokine receptors depends critically on receptor orientation

Finer-Moore, J, Wendoloski, JJ, Egrie, J, Li, C, Chirino, AJ, Zhang, J, Katz, BA, Matthews, DJ, Syed, RS, Stroud, RM, Aoki, KH, Osslund, TD, Sitney, K, Elliott, S, Reid, SW, Zhan, H, Liu, B, Cheetham, JC

Nature 1998
11231127 Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

Langosch, D, Ruan, W, Watowich, SS, Cohen, J, Ketteler, R, Klingmüller, U, Gurezka, R, Neumann, D, Kubatzky, KF

Curr. Biol. 2001
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Epo binds Epor:Jak2:Lyn:Irs2 (Mus musculus)
Authored
May, B  (2017-04-22)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-05-13)
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