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EPHB4 [plasma membrane]
Stable Identifier
R-HSA-2682323
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ephrin type-B receptor 4 ecNumber2.7.10.1/ecNumber, EPHB4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH receptors autophosphorylate (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
MMP2,9 cleave EPHB (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPH:EFN dimers tetramerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPH:EFN tetramers oligomerise (Homo sapiens)
EPH-EFN dimers [plasma membrane] (Homo sapiens)
EPHB:EFNB dimers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPH-ephrin oligomers [plasma membrane] (Homo sapiens)
EPHB:EFNB oligomers [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs bind EFNBs (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EFNBs bind SDCBP (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SDCBP [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EFNBs bind SFKs (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
SFKs phosphorylate GIT1 (Homo sapiens)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
EPHBs [plasma membrane] (Homo sapiens)
EPHB4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54760 EPHB4
Gene Names
EPHB4, HTK, MYK1, TYRO11
Chain
signal peptide:1-15, chain:16-987
Reference Genes
BioGPS Gene:2050 EPHB4
COSMIC (genes):EPHB4 EPHB4
CTD Gene:2050 EPHB4
dbSNP Gene:2050 EPHB4
ENSEMBL:ENSG00000196411 EPHB4
HGNC:3395 EPHB4
KEGG:hsa:2050 EPHB4
Monarch:2050 EPHB4
NCBI Gene:2050 EPHB4
OMIM:600011 EPHB4
UCSC:P54760 EPHB4
Reference Transcript
RefSeq:NM_004444.4 EPHB4
Other Identifiers
11735754_a_at
11745755_a_at
11752791_a_at
11753070_a_at
11753406_a_at
1351_at
17060758
202894_PM_at
202894_at
2050
216680_PM_s_at
216680_s_at
3064294
3064295
3064296
3064297
3064298
3064299
3064300
3064301
3064302
3064303
3064304
3064305
3064307
3064308
3064309
3064310
3064311
3064312
3064313
3064314
3064315
3064316
3064317
3064319
3064320
3064321
3064322
3064323
3064325
3064326
3064327
3064329
3064330
3064332
3064333
8141625
A_23_P168443
A_33_P3216532
GE62563
GO:0001525
GO:0002042
GO:0003007
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005515
GO:0005524
GO:0005576
GO:0005829
GO:0005886
GO:0006468
GO:0007155
GO:0007169
GO:0016020
GO:0016740
GO:0043226
GO:0043235
GO:0046777
GO:0048013
GO:0048870
GO:0060089
GO:0070062
GO:0140096
HMNXSV003031936
Hs.155227.1.S1_3p_a_at
ILMN_2214910
PH_hs_0025562
TC07001677.hg
U07695_at
g4758289_3p_at
Participates
as a member of
EPHBs [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y590,Y596-EPHB4 [plasma membrane]
EPHB4 (16-?) [extracellular region]
EPHB4 (?-987) [plasma membrane]
EPHB4 (?-987) [cytosol]
EPHB4 (?-?) [plasma membrane]
Inferred To
EPHB4 [plasma membrane]
(Bos taurus)
EPHB4 [plasma membrane]
(Caenorhabditis elegans)
EPHB4 [plasma membrane]
(Canis familiaris)
EPHB4 [plasma membrane]
(Danio rerio)
EPHB4 [plasma membrane]
(Drosophila melanogaster)
EPHB4 [plasma membrane]
(Mus musculus)
EPHB4 [plasma membrane]
(Rattus norvegicus)
EPHB4 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004435.3
ZINC - World Drugs
EPHB4_HUMAN
Guide to Pharmacology - Targets
1833
OpenTargets
ENSG00000196411
ENSEMBL
ENSP00000350896
,
ENST00000358173
,
ENST00000616502
,
ENSP00000482702
ZINC - FDA approved
EPHB4_HUMAN
ZINC - Substances
EPHB4_HUMAN
ZINC - Biogenic
EPHB4_HUMAN
ZINC target
P54760
PRO
P54760
PDB
2E7H
,
6FNI
,
4BB4
,
2VWU
,
2VWV
,
4AW5
,
6FNJ
,
2YN8
,
6FNK
,
2VWW
,
2X9F
,
3ZEW
,
2XVD
,
2VWX
,
6FNM
,
6FNL
,
2VWY
,
2BBA
,
2VX0
,
2VWZ
,
2VX1
,
2HLE
,
2QKQ
ZINC - Investigational
EPHB4_HUMAN
ZINC - Metabolites
EPHB4_HUMAN
IntEnz
2.7.10.1
HPA
ENSG00000196411-EPHB4
Pharos - Targets
P54760
ZINC - Predictions - Purchasable
EPHB4_HUMAN
HMDB Protein
HMDBP01296
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01588 EPO
1
EPO [extracellular region]
(R-HSA-379001)
0.544
6
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