Reactome | GRPR [plasma membrane]

GRPR [plasma membrane]

Stable Identifier

R-HSA-375363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gastrin-releasing peptide receptor, GRPR_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bombesin-like receptors bind bombesin homologues (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        GRPR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30550 GRPR

Gene Names

GRPR

Chain

chain:1-384

Reference Genes

BioGPS Gene:2925 GRPR

COSMIC (genes):GRPR GRPR

CTD Gene:2925 GRPR

dbSNP Gene:2925 GRPR

ENSEMBL:ENSG00000126010 GRPR

HGNC:4609 GRPR

KEGG:hsa:2925 GRPR

Monarch:2925 GRPR

NCBI Gene:2925 GRPR

OMIM:305670 GRPR

UCSC:P30550 GRPR

Reference Transcript

RefSeq:NM_005314.2 GRPR

Other Identifiers

11740435_at

11740436_at

17101775

207929_PM_at

207929_at

2925

32430_at

3970025

3970026

3970032

3970033

3970034

3970035

8166202

A_14_P201775

A_23_P62255

A_24_P357266

GE58058

GO:0004930

GO:0005886

GO:0007186

GO:0007200

GO:0007218

GO:0007611

GO:0008188

GO:0008528

GO:0016020

GO:0035176

GO:0036343

GO:0042127

GO:0042923

GO:0043207

GO:0050877

GO:0060089

GO:0061744

GO:1903942

GO:2000987

HMNXSV003026399

ILMN_1813851

ILMN_2119123

M73481_at

PH_hs_0004223

TC0X000073.hg

g4885360_3p_at

Participates

as a member of

Bombesin-like receptor [plasma membrane] (Homo sapiens)

Inferred To

CCHa1-R [plasma membrane] (Drosophila melanogaster)

grpr [plasma membrane] (Xenopus tropicalis)

Grpr [plasma membrane] (Mus musculus)

Grpr [plasma membrane] (Rattus norvegicus)

GRPR [plasma membrane] (Bos taurus)

GRPR [plasma membrane] (Canis familiaris)

GRPR [plasma membrane] (Gallus gallus)

GRPR [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_005305.1

Guide to Pharmacology - Targets

ENSEMBL

ENSP00000369643, ENST00000380289

OpenTargets

ENSG00000126010

ZINC - Substances

GRPR_HUMAN

ZINC target

P30550

PRO

P30550

GlyGen

P30550

PDB

7W40, 7W41, 8H0Q, 7W3Z

HPA

ENSG00000126010-GRPR

Pharos - Targets

P30550

ZINC - Predictions - Purchasable

GRPR_HUMAN

HMDB Protein

HMDBP07721

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.527	2
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:P61224 RAP1B	2	RAP1B [plasma membrane] (R-HSA-377590) RAP1B [azurophil granule membrane] (R-HSA-6804972)	0.527	2
UniProt:P53701 HCCS	1	HCCS [mitochondrial inner membrane] (R-HSA-9866218)	0.527	2
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.527	2
UniProt:Q7L8W6 DPH6	1	DPH6 [cytosol] (R-HSA-5358469)	0.527	2
UniProt:Q70CQ3 USP30	2	USP30 [mitochondrial outer membrane] (R-HSA-5696931) USP30 [peroxisomal membrane] (R-HSA-9674135)	0.527	2