Reactome | GRPR [plasma membrane]

GRPR [plasma membrane]

Stable Identifier

R-CFA-375363

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

GRPR, E2QTA7

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        GPCRs that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Bombesin-like receptors bind bombesin homologues (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Canis familiaris)
        
        Bombesin-like receptor [plasma membrane] (Canis familiaris)
        
        GRPR [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2QTA7

Gene Names

GRPR

Reference Genes

BioGPS Gene:491754 GRPR

ENSEMBL:ENSCAFG00000012273

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000012273 GRPR

KEGG Gene (Canis lupus familiaris):491754 GRPR

Monarch:491754 GRPR

NCBI Gene:491754 GRPR

Reference Transcript

RefSeq:XM_014111958.1 GRPR

Other Identifiers

491754

CfaAffx.19058.1.S1_at

GO:0003674

GO:0004930

GO:0005575

GO:0005886

GO:0005887

GO:0007165

GO:0007186

GO:0007200

GO:0007218

GO:0008150

GO:0008188

GO:0008283

GO:0008528

GO:0016020

GO:0016021

GO:0035176

GO:0036343

GO:0042127

GO:0043207

GO:0061744

Participant Of

hasMember

Bombesin-like receptor [plasma membrane]

Inferred From

GRPR [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_013967433.1

OpenTargets

ENSG00000126010

Ensembl

ENSCAFT00000019488, ENSCAFG00000012273, ENSCAFP00000018079

VGNC

41519

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