Reactome | APBB1IP [cytosol]

APBB1IP

Stable Identifier

R-HSA-354081

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIAM, Amyloid beta A4 precursor protein-binding family B member 1- interacting protein

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Signaling by BRAF and RAF fusions (Homo sapiens)
      - Dissociation of BRAF/RAF fusion complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Signaling by high-kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Dissociation of high activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin alphaIIb beta3 signaling (Homo sapiens)
      - Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Activation of Talin (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Autophosphorylation of FADK1 at Y397 (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Autophosphorylation of SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
        
        Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        SOS bound to Grb2:pFADK1 [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Recruitment of GRB2 to p-FADK1 (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta3 activation (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Phosphorylation of pFADK1 by SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Release of CSK from SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - SYK activation by SRC (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Translocation of FADK1 to Focal complexes (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Translocation of RIAM to plasma membrane (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        Crk bound to p130Cas:FADK1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Phosphorylation of p130Cas by SRC-FADK1 complex (Homo sapiens)
        
        FADK1 bound p130Cas complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Recruitment of p130Cas to FADK1 (Homo sapiens)
        
        FADK1 bound p130Cas complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Integrin signaling (Homo sapiens)
  - Integrin alphaIIb beta3 signaling (Homo sapiens)
    - Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
      - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Activation of Talin (Homo sapiens)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Autophosphorylation of FADK1 at Y397 (Homo sapiens)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Autophosphorylation of SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
      - Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
      - Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        SOS bound to Grb2:pFADK1 [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Recruitment of GRB2 to p-FADK1 (Homo sapiens)
        
        GRB2 bound to pFADK1 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Integrin alphaIIb beta3 activation (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
      - Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Phosphorylation of pFADK1 by SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Release of CSK from SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
      - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
      - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - SYK activation by SRC (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Translocation of FADK1 to Focal complexes (Homo sapiens)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - Translocation of RIAM to plasma membrane (Homo sapiens)
      - APBB1IP [cytosol] (Homo sapiens)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
    - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
      - Crk binding to p130cas (Homo sapiens)
        
        Crk bound to p130Cas:FADK1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Phosphorylation of p130Cas by SRC-FADK1 complex (Homo sapiens)
        
        FADK1 bound p130Cas complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Phosphorylated p130Cas in complex with FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
      - Recruitment of p130Cas to FADK1 (Homo sapiens)
        
        FADK1 bound p130Cas complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex [plasma membrane] (Homo sapiens)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Homo sapiens)
        
        APBB1IP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z5R6 APBB1IP

Gene Names

APBB1IP, PREL1, RARP1, RIAM

Chain

chain:1-666

Reference Genes

BioGPS Gene:54518 APBB1IP

COSMIC (genes):APBB1IP APBB1IP

CTD Gene:54518 APBB1IP

dbSNP Gene:54518 APBB1IP

ENSEMBL:ENSG00000077420 APBB1IP

HGNC:17379 APBB1IP

KEGG Gene (Homo sapiens):hsa:54518 APBB1IP

Monarch:54518 APBB1IP

NCBI Gene:54518 APBB1IP

OMIM:609036 APBB1IP

UCSC:Q7Z5R6 APBB1IP

Reference Transcript

Other Identifiers

0006040524

11726421_a_at

11761034_at

1554571_at

16703407

17009

219994_at

230925_at

2MWN

3239761

3239762

3239775

3239777

3239779

3239780

3239781

3239782

3239783

3239787

3239788

3239789

3239791

3239794

3239796

3239801

3239802

3239803

3239807

3239808

3239809

3239810

3239811

3ZDL

54518

56059_at

63903

7926786

81690_at

A_14_P122182

A_14_P128344

A_23_P12549

A_23_P401700

A_24_P232365

AAH35636

AAH54516

AAN75525

AB085852

AL160287

AL355798

APBB1IP

APBB1IP-201

APBB1IP-202

AY152730

BAC41256

BC035636

BC054516

CCDS31167

CH471072

EAW86097

ENSG00000077420

ENSP00000349237

ENSP00000365411

ENST00000356785

ENST00000376236

EntrezGene:54518

GE55630

GO:0002291

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007155

GO:0007165

GO:0008150

GO:0016020

GO:0030027

GO:0030054

GO:0042101

GO:0042995

GO:0043226

GO:0045785

HGNC:17379

HPA017009

HPA063903

Hs.122910.0.A1_3p_at

Hs2.397115.1.S1_3p_at

ILMN_1801710

IPR000159

IPR001849

IPR011993

IPR029071

MIM:609036

NM_019043

NP_061916

PF00169

PF00788

PH_hs_0024575

SM00233

SM00314

TC10000181.hg

uc001isr.4

uc001iss.4

UPI000007422E

UPI00001AF165

XM_006717451

XM_011519514

XP_006717514

XP_011517816

Participant Of

input

Translocation of RIAM to plasma membrane

hasComponent

Rap1-GTP:PIP2:RIAM [plasma membrane]

Inferred To

APBB1IP [cytosol] (Bos taurus)

APBB1IP [cytosol] (Caenorhabditis elegans)

APBB1IP [cytosol] (Canis familiaris)

APBB1IP [cytosol] (Danio rerio)

APBB1IP [cytosol] (Drosophila melanogaster)

APBB1IP [cytosol] (Gallus gallus)

APBB1IP [cytosol] (Mus musculus)

APBB1IP [cytosol] (Rattus norvegicus)

APBB1IP [cytosol] (Sus scrofa)

APBB1IP [cytosol] (Taeniopygia guttata)

APBB1IP [cytosol] (Xenopus tropicalis)

Homologues of APBB1IP [cytosol] (Drosophila melanogaster)

Homologues of APBB1IP [cytosol] (Gallus gallus)

Homologues of APBB1IP [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_006717514.1, NP_061916.3

GeneCards

Q7Z5R6

DOCK Blaster

3ZDL

PRO

Q7Z5R6

PDB

3ZDL, 2MWN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IUH5 ZDH17			0.508	2