Reactome | Apbb1ip [cytosol]

Apbb1ip [cytosol]

Stable Identifier

R-MMU-354081

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

APBB1IP, Q8R5A3

Locations in the PathwayBrowser

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Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Platelet Aggregation (Plug Formation) (Mus musculus)
    - Integrin signaling (Mus musculus)
      - Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Activation of Talin (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Autophosphorylation of PTK2 at Y397 (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Autophosphorylation of SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
        
        Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Recruitment of GRB2 to p-PTK2 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Integrin alphaIIb beta3 activation (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Phosphorylation of pPTK2 by SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Release of CSK from SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - SYK activation by SRC (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - SYK binds to integrin alphaIIb beta3 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Translocation of PTK2 to Focal complexes (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Translocation of RIAM to plasma membrane (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
        
        Crk binding to p130cas (Mus musculus)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Recruitment of BCAR1 to PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Integrin signaling (Mus musculus)
  - Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Activation of Talin (Mus musculus)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
      - Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Autophosphorylation of PTK2 at Y397 (Mus musculus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Autophosphorylation of SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
    - Focal complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
    - Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Recruitment of GRB2 to p-PTK2 (Mus musculus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Integrin alphaIIb beta3 activation (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
    - Focal complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Phosphorylation of pPTK2 by SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Release of CSK from SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - SYK activation by SRC (Mus musculus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - SYK binds to integrin alphaIIb beta3 (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Translocation of PTK2 to Focal complexes (Mus musculus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
  - Translocation of RIAM to plasma membrane (Mus musculus)
    - Apbb1ip [cytosol] (Mus musculus)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
      - Apbb1ip [cytosol] (Mus musculus)
  - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
    - Crk binding to p130cas (Mus musculus)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
    - Recruitment of BCAR1 to PTK2 complex (Mus musculus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)
        
        Apbb1ip [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8R5A3

Gene Names

Apbb1ip

Reference Genes

BioGPS Gene:54519 Apbb1ip

ENSEMBL:ENSMUSG00000026786

KEGG:mmu:54519 Apbb1ip

Monarch:54519 Apbb1ip

NCBI Gene:54519 Apbb1ip

UCSC:Q8R5A3 Apbb1ip

Reference Transcript

Other Identifiers

102710_at

10469695

1425269_at

17367536

4312104

4358738

4383315

4453039

4523895

4524808

4617077

4638579

4646038

4649295

4701347

4803369

5068838

5117883

5150438

5194926

5246772

5307494

5415761

5436399

5444647

54519

5474057

5515162

5561077

5582987

5597059

AF020313_at

A_52_P300981

A_52_P33221

A_55_P1961009

A_55_P2504765

GE1437362

GE33213

GO:0002291

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007165

GO:0016020

GO:0030027

GO:0042101

GO:0042995

GO:0045785

GO:0070161

ILMN_1229575

ILMN_2671847

ILMN_2755666

ILMN_2755667

ILMN_2755668

ILMN_2967824

mMC024927

mMR028493

Participates

as an input of

Translocation of RIAM to plasma membrane (Mus musculus)

as a component of

Rap1-GTP:PIP2:RIAM [plasma membrane] (Mus musculus)

Inferred From

APBB1IP [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUSP00000014290, ENSMUSG00000026786, ENSMUST00000014290

PRO

Q8R5A3

MGI

1861354

PDB

6O6H, 3TCA, 4W8P, 7V1A, 4KVG, 6OLU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26039 Tln1	4	Tln1 [cytosol] (R-MMU-9855035) Tln1(433-2541) [cytosol] (R-MMU-9855172) Tln1(1-432) [cytosol] (R-MMU-9855103) Tln1 [extracellular region] (R-MMU-350693)	0.737	8
UniProt:Q03173 Enah	2	Enah [cytosol] (R-MMU-430212) Enah [cytosol] (R-MMU-426406)	0.524	7
UniProt:P70460 Vasp	2	Vasp [cytosol] (R-MMU-430199) Vasp [cytosol] (R-MMU-446323)	0.524	3
UniProt:Q61411 Hras	8	S-Farn-Me HRAS [plasma membrane] (R-MMU-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-MMU-9647896) proHRAS [cytosol] (R-MMU-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-MMU-9647918) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-MMU-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-MMU-9647788) Hras [plasma membrane] (R-MMU-1250504) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-MMU-9647912)	0.524	2

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