Reactome | Translocation of RIAM to plasma membrane

Translocation of RIAM to plasma membrane

Stable Identifier

R-HSA-354060

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Translocation of RIAM to plasma membrane

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Upon the production of activated Rap1A at the plasma membrane, RIAM interacts with Rap1A-GTP with its N-ter RA domain, and with its C-ter PH domain it interacts with PIP2.

Literature References

PubMed ID	Title	Journal	Year
16757337	Rap1 regulation of RIAM and cell adhesion Lafuente, E, Boussiotis, VA	Methods Enzymol	2006
17624957	Platelet integrins and immunoreceptors Kasirer-Friede, A, Kahn, ML, Shattil, SJ	Immunol Rev	2007
15469846	RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Lafuente, EM, van Puijenbroek, AA, Krause, M, Carman, CV, Freeman, GJ, Berezovskaya, A, Constantine, E, Springer, TA, Gertler, FB, Boussiotis, VA	Dev Cell	2004