Reactome | APBB1IP [cytosol]

APBB1IP [cytosol]

Stable Identifier

R-CFA-354081

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

APBB1IP, A0A8I3N737

Locations in the PathwayBrowser

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Hemostasis (Canis familiaris)

- Platelet activation, signaling and aggregation (Canis familiaris)
  - Platelet Aggregation (Plug Formation) (Canis familiaris)
    - Integrin signaling (Canis familiaris)
      - Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Activation of Talin (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Autophosphorylation of PTK2 at Y397 (Canis familiaris)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Autophosphorylation of SRC (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
        
        Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Recruitment of GRB2 to p-PTK2 (Canis familiaris)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Integrin alphaIIb beta3 activation (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Phosphorylation of pPTK2 by SRC (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Release of CSK from SRC (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - SYK activation by SRC (Canis familiaris)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - SYK binds to integrin alphaIIb beta3 (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Translocation of PTK2 to Focal complexes (Canis familiaris)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Translocation of RIAM to plasma membrane (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
        
        Crk binding to p130cas (Canis familiaris)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Integrin signaling (Canis familiaris)
  - Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Activation of Talin (Canis familiaris)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
      - APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Autophosphorylation of PTK2 at Y397 (Canis familiaris)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Autophosphorylation of SRC (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)
    - Focal complex [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)
    - Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Canis familiaris)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Recruitment of GRB2 to p-PTK2 (Canis familiaris)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Integrin alphaIIb beta3 activation (Canis familiaris)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)
    - Focal complex [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Phosphorylation of pPTK2 by SRC (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Release of CSK from SRC (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - SHC1 dissociates from integrin alphaIIb beta3 (Canis familiaris)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Canis familiaris)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - SYK activation by SRC (Canis familiaris)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - SYK binds to integrin alphaIIb beta3 (Canis familiaris)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Translocation of PTK2 to Focal complexes (Canis familiaris)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
      - Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
  - Translocation of RIAM to plasma membrane (Canis familiaris)
    - APBB1IP [cytosol] (Canis familiaris)
    - Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
      - APBB1IP [cytosol] (Canis familiaris)
  - p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
    - Crk binding to p130cas (Canis familiaris)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Canis familiaris)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
    - Recruitment of BCAR1 to PTK2 complex (Canis familiaris)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        Dissociation of RAS:RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        RAF phosphorylates MAP2K dimer (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
        
        RAF/MAPK scaffolds [cytosol] (Canis familiaris)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
        
        Focal complex [plasma membrane] (Canis familiaris)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Talin:RIAM complex [plasma membrane] (Canis familiaris)
        
        Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)
        
        APBB1IP [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N737

Gene Names

APBB1IP

Reference Genes

ENSEMBL:ENSCAFG00845003856.1

UCSC:A0A8I3N737 APBB1IP

Other Identifiers

477985

CfaAffx.7406.1.S1_s_at

CfaAffx.7409.1.S1_s_at

GO:0002291

GO:0005829

GO:0005886

GO:0007165

GO:0042101

GO:0045785

Participates

as an input of

Translocation of RIAM to plasma membrane (Canis familiaris)

as a component of

Rap1-GTP:PIP2:RIAM [plasma membrane] (Canis familiaris)

Inferred From

APBB1IP [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845003856, ENSCAFP00845005527, ENSCAFT00845006937

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