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DSC2 [plasma membrane]
Stable Identifier
R-HSA-6814398
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmocollin-2, DSC2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02487 DSC2
Gene Names
DSC2, CDHF2, DSC3
Chain
signal peptide:1-27, propeptide:28-135, chain:136-901
Reference Genes
BioGPS Gene:1824 DSC2
COSMIC (genes):DSC2 DSC2
COSMIC (genes):DSC3 DSC2
CTD Gene:1824 DSC2
dbSNP Gene:1824 DSC2
ENSEMBL:ENSG00000134755 DSC2
HGNC:3036 DSC2
Monarch:1824 DSC2
NCBI Gene:1824 DSC2
OMIM:125645 DSC2
UCSC:Q02487 DSC2
Reference Transcript
RefSeq:NM_024422.4 DSC2
RefSeq:NM_004949.4 DSC2
Other Identifiers
11725530_a_at
11725531_a_at
11725532_a_at
11737096_a_at
11737097_a_at
11757702_s_at
16854486
1824
204750_PM_s_at
204750_s_at
204751_PM_x_at
204751_x_at
226817_PM_at
226817_at
231033_PM_at
231033_at
3802943
3802977
3802979
3802981
3802982
3802983
3802984
3802985
3802987
3802989
3802990
3802991
3802992
3802995
3802996
3802998
3802999
3803000
3803001
3803002
3803003
3803004
3803005
3803006
3803007
3803008
3803009
3803010
3803012
3803013
3803014
3803015
3803023
39302_at
47578_at
76068_at
8022711
A_23_P4494
GE80526
GE88450
GE893257
GO:0001533
GO:0005509
GO:0005515
GO:0005783
GO:0005886
GO:0005912
GO:0007155
GO:0007156
GO:0009267
GO:0014704
GO:0016020
GO:0030057
GO:0031410
GO:0043226
GO:0046872
GO:0070062
GO:0070161
GO:0086042
GO:0086073
GO:0086083
GO:0086091
GO:0098609
GO:0098631
GO:0098911
HMNXSV003014220
HMNXSV003028682
Hs.106243.0.A1_3p_at
Hs.239727.0.S1_3p_a_at
Hs.95612.0.A1_3p_at
ILMN_1663119
ILMN_2381257
PH_hs_0022220
TC18000436.hg
TC18000882.hg
U51711_at
X56807_at
g13435365_3p_a_at
p7690
Participates
as a member of
Desmocolins [plasma membrane] (Homo sapiens)
Other forms of this molecule
DSC2 [cornified envelope]
Inferred To
DSC1 [plasma membrane]
(Canis familiaris)
dsc2l [plasma membrane]
(Danio rerio)
Dsc2 [plasma membrane]
(Mus musculus)
Dsc2 [plasma membrane]
(Rattus norvegicus)
cdh-4 [plasma membrane]
(Caenorhabditis elegans)
DSC2 [plasma membrane]
(Bos taurus)
DSC2 [plasma membrane]
(Gallus gallus)
DSC2 [plasma membrane]
(Sus scrofa)
dsc3 [plasma membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000251081
,
ENSP00000280904
,
ENST00000251081
,
ENST00000280904
OpenTargets
ENSG00000134755
HPA
ENSG00000134755-DSC2
PRO
Q02487
Pharos - Targets
Q02487
Orphanet
DSC2
HMDB Protein
HMDBP07656
PDB
5ERP
,
7A7D
,
5J5J
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