In apoptotic cells, intercellular contacts are disrupted through the activity of caspases. Apoptotic cleavage of Dsg2,the most widespread desmosomal cadherin, is mediated by caspase 3 in epithelial cells (Cirillo et al., 2008).
La Gatta, A, Lanza, A, Gombos, F, Cammarota, M, De Rosa, A, Cirillo, N, Lanza, M
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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