Caspase-mediated cleavage of Desmoglein 2

Stable Identifier
R-HSA-351877
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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Caspase-mediated cleavage of Desmoglein 2
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In apoptotic cells, intercellular contacts are disrupted through the activity of caspases. Apoptotic cleavage of Dsg2,the most widespread desmosomal cadherin, is mediated by caspase 3 in epithelial cells (Cirillo et al., 2008).

Literature References
PubMed ID Title Journal Year
17559062 The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

La Gatta, A, Lanza, A, Gombos, F, Cammarota, M, De Rosa, A, Cirillo, N, Lanza, M

J Cell Biochem 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Desmoglein 2 (Caenorhabditis elegans)
Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)
Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)
Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)
Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)
Caspase-mediated cleavage of Desmoglein 2 (Sus scrofa)
Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-28)
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