Caspase-mediated cleavage of Desmoglein 2

Stable Identifier
R-HSA-351877
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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Caspase-mediated cleavage of Desmoglein 2
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In apoptotic cells, intercellular contacts are disrupted through the activity of caspases. Apoptotic cleavage of Dsg2,the most widespread desmosomal cadherin, is mediated by caspase 3 in epithelial cells (Cirillo et al., 2008).

Literature References
PubMed ID Title Journal Year
17559062 The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

Cirillo, N, Lanza, M, De Rosa, A, Cammarota, M, La Gatta, A, Gombos, F, Lanza, A

J Cell Biochem 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of Desmoglein 2 (Canis familiaris)
Caspase-mediated cleavage of Desmoglein 2 (Drosophila melanogaster)
Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)
Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)
Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)
Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-29)