Caspase-mediated cleavage of Desmoglein 2

Stable Identifier
R-HSA-351877
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of Desmoglein 2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In apoptotic cells, intercellular contacts are disrupted through the activity of caspases. Apoptotic cleavage of Dsg2,the most widespread desmosomal cadherin, is mediated by caspase 3 in epithelial cells (Cirillo et al., 2008).

Literature References
PubMed ID Title Journal Year
17559062 The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

Cirillo, N, Lanza, M, De Rosa, A, Cammarota, M, La Gatta, A, Gombos, F, Lanza, A

J Cell Biochem 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of Desmoglein 2 (Canis familiaris)
Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)
Caspase-mediated cleavage of Desmoglein 2 (Drosophila melanogaster)
Caspase-mediated cleavage of Desmoglein 2 (Gallus gallus)
Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)
Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)
Caspase-mediated cleavage of Desmoglein 2 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-29)
Cite Us!