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CYTH3 [Golgi membrane]
Stable Identifier
R-HSA-8847833
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
ARNO3, Cytohesin-3, ARF nucleotide-binding site opener 3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
CYTH proteins bind ARF1:GTP (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH3 [Golgi membrane] (Homo sapiens)
CYTH proteins stimulate ARF1 GTPase activity (Homo sapiens)
ARF1:GDP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH3 [Golgi membrane] (Homo sapiens)
ARF1:GTP:CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH1,2,3,4 [Golgi membrane] (Homo sapiens)
CYTH3 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43739 CYTH3
Gene Names
CYTH3, ARNO3, GRP1, PSCD3
Chain
chain:1-400
Reference Genes
BioGPS Gene:9265 CYTH3
COSMIC (genes):CYTH3 CYTH3
CTD Gene:9265 CYTH3
dbSNP Gene:9265 CYTH3
ENSEMBL:ENSG00000008256 CYTH3
HGNC:9504 CYTH3
KEGG Gene (Homo sapiens):9265 CYTH3
Monarch:9265 CYTH3
NCBI Gene:9265 CYTH3
OMIM:605081 CYTH3
UCSC:O43739 CYTH3
Reference Transcript
RefSeq:NM_004227.3 CYTH3
Other Identifiers
0000770377
11717810_a_at
11757447_s_at
17054980
206523_at
225147_at
243752_3p_s_at
243752_s_at
3037249
3037250
3037252
3037253
3037254
3037255
3037256
3037257
3037258
3037267
3037269
3037270
3037272
3037273
3037276
3037277
3037278
3037279
3037297
3037298
34919_at
55013_at
71182_at
8138067
9265
A_23_P111593
A_33_P3271051
GE79074
GO:0000139
GO:0001726
GO:0003674
GO:0005085
GO:0005086
GO:0005515
GO:0005547
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005912
GO:0005923
GO:0006810
GO:0007155
GO:0007165
GO:0008150
GO:0008289
GO:0016020
GO:0016192
GO:0019899
GO:0030054
GO:0031234
GO:0032012
GO:0043167
GO:0043226
GO:0045785
GO:0048193
GO:0090162
Hs.212425.0.A1_3p_s_at
Hs.7984.0.S1_3p_at
ILMN_1713918
ILMN_2160727
PH_hs_0000840
TC07001127.hg
g8670548_3p_at
Participant Of
hasMember
CYTH1,2,3,4 [Golgi membrane]
Other forms of this molecule
CYTH3 [cytosol]
Inferred To
sec74 [Golgi membrane] (Schizosaccharomyces pombe)
Cyth3 [Golgi membrane] (Mus musculus)
Cyth3 [Golgi membrane] (Rattus norvegicus)
grp-1 [Golgi membrane] (Caenorhabditis elegans)
SYT1 [Golgi membrane] (Saccharomyces cerevisiae)
step [Golgi membrane] (Drosophila melanogaster)
CYTH3 [Golgi membrane] (Bos taurus)
CYTH3 [Golgi membrane] (Canis familiaris)
CYTH3 [Golgi membrane] (Gallus gallus)
CYTH3 [Golgi membrane] (Sus scrofa)
CYTH2 [Golgi membrane] (Dictyostelium discoideum)
CYTH2 [Golgi membrane] (Plasmodium falciparum)
cyth3 [Golgi membrane] (Xenopus tropicalis)
sec73 [Golgi membrane] (Schizosaccharomyces pombe)
Homologues of CYTH2 [Golgi membrane] (Dictyostelium discoideum)
Homologues of CYTH2 [Golgi membrane] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_004218.1
OpenTargets
ENSG00000008256
GeneCards
O43739
HPA
ENSG00000008256-CYTH3
ZINC target
O43739
Ensembl
ENSP00000297044
,
ENST00000350796
,
ENSP00000379967
,
ENSG00000008256
,
ENST00000396741
PRO
O43739
ZINC - Predictions - Purchasable
CYH3_HUMAN
HMDB Protein
HMDBP08340
PDB
6U3G
,
6U3E
,
4KAX
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
6
PI(3,4,5)P3 [endocytic vesicle membrane]
(R-ALL-917725)
PIP3 [plasma membrane]
(R-ALL-38117)
PI(3,4,5)P3 [endosome membrane]
(R-ALL-917716)
PI(3,4,5)P3 [early endosome membrane]
(R-ALL-8849955)
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
(R-ALL-8874468)
PI(3,4,5)P3 [plasma membrane]
(R-ALL-179838)
0.59
2
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.556
3
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