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NCOR1, NCOR2 [nucleoplasm]
Stable Identifier
R-HSA-349716
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NCOR corepressor protein
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC3 containing complexes deacetylate histone (Homo sapiens)
HDAC3-containing complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Differentiation of T cells (Homo sapiens)
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) (Homo sapiens)
STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
PRC1:RBPJ:NCOR:GATA3 gene [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
HDAC3-containing complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Notch-HLH transcription pathway (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ABCA1 (Homo sapiens)
ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Homo sapiens)
Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
Co-repressor complex dissociates from the transcription unit of the ABCA1 gene (Homo sapiens)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)
ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
NCOR1, NCOR2 [nucleoplasm] (Homo sapiens)
Participants
members
NCOR1 [nucleoplasm]
(Homo sapiens)
NCOR2 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (Homo sapiens)
STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) (Homo sapiens)
Ubiquitination of SKI/SKIL by Rnf111 (Homo sapiens)
Ubiquitination of SKI/SKIL by RNF111/SMURF2 (Homo sapiens)
as a component of
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NCOR [nucleoplasm] (Homo sapiens)
NCOR:GPS2:TBL1:HDAC3 [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
HDAC3-containing complex [nucleoplasm] (Homo sapiens)
NCOR:HDAC1:Tbl1 [nucleoplasm] (Cercopithecus aethiops)
CSL NCOR co-repressor complex [nucleoplasm] (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Homo sapiens)
as an input of
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)
Inferred To
Smr [nucleoplasm]
(Drosophila melanogaster)
NCOR1, NCOR2 [nucleoplasm]
(Bos taurus)
NCOR1, NCOR2 [nucleoplasm]
(Canis familiaris)
NCOR1, NCOR2 [nucleoplasm]
(Gallus gallus)
NCOR1, NCOR2 [nucleoplasm]
(Mus musculus)
NCOR1, NCOR2 [nucleoplasm]
(Sus scrofa)
gei-8 [nucleoplasm]
(Caenorhabditis elegans)
Ncor2 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of NCOR1, NCOR2 [nucleoplasm]
(Xenopus tropicalis)
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