Ubiquitination of SKI/SKIL by RNF111/SMURF2

Stable Identifier
R-HSA-2186747
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007, Nagano et al. 2007) and SMURF2 (Bonni et al. 2001) ubiquitinate SKI/SKIL transcriptional repressors bound to activated SMAD2/3. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL. The role of SMURF2 was inferred from experiments involving human proteins only.

Literature References
PubMed ID Title Journal Year
17510063 Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

Nagano, Y, Mavrakis, KJ, Lee, KL, Fujii, T, Koinuma, D, Sase, H, Yuki, K, Isogaya, K, Saitoh, M, Imamura, T, Episkopou, V, Miyazono, K, Miyazawa, K

J Biol Chem 2007
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS

Mol Cell Biol 2007
11389444 TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

Bonni, S, Wang, HR, Causing, CG, Kavsak, P, Stroschein, SL, Luo, K, Wrana, JL

Nat Cell Biol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created