Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

Stable Identifier
Reaction [dissociation]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In transient transfection assays performed in human hepatoma HepG2 cells, NR1H3 (LXR alpha) was found to interact with the nuclear receptor corepressor (NCOR) and nuclear receptor coactivator 1 (NCOA1 or SRC1) to regulate the UGT1A3 gene promoter (Verreault M et al. 2006). In the unliganded state, LXR:RXR heterodimers are bound to DNA response elements in association with co-repressor complexes resulting in repression of target genes (Wagner BL et al. 2003). Ligand binding to LXR induces conformational changes leading to release of co-repressor complexes and recruitment of co-activator complexes and transcription of target genes.

Literature References
PubMed ID Title Journal Year
16871576 The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice

Kaeding, J, Verreault, M, Trottier, J, Caron, P, Staels, B, Tukey, RH, Bonzo, JA, BĂ©langer, J, Barbier, O, Senekeo-Effenberger, K

Hepatology 2006
22541735 Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

Jakobsson, T, Gustafsson, JA, Steffensen, KR, Treuter, E

Trends Pharmacol. Sci. 2012
Orthologous Events
Cite Us!