Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

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R-HSA-9029566
Type
Reaction [dissociation]
Species
Homo sapiens
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In transient transfection assays performed in human hepatoma HepG2 cells, NR1H3 (LXR alpha) was found to interact with the nuclear receptor corepressor (NCOR) and nuclear receptor coactivator 1 (NCOA1 or SRC1) to regulate the UGT1A3 gene promoter (Verreault M et al. 2006). In the unliganded state, LXR:RXR heterodimers are bound to DNA response elements in association with co-repressor complexes resulting in repression of target genes (Wagner BL et al. 2003). Ligand binding to LXR induces conformational changes leading to release of co-repressor complexes and recruitment of co-activator complexes and transcription of target genes.

Literature References
PubMed ID Title Journal Year
22541735 Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

Jakobsson, T, Treuter, E, Gustafsson, JA, Steffensen, KR

Trends Pharmacol. Sci. 2012
16871576 The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice

Verreault, M, Senekeo-Effenberger, K, Trottier, J, Bonzo, JA, BĂ©langer, J, Kaeding, J, Staels, B, Caron, P, Tukey, RH, Barbier, O

Hepatology 2006
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