Ubiquitination of SKI/SKIL by Rnf111

Stable Identifier
R-NUL-2186755
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Ubiquitination of SKI/SKIL by Rnf111

Recombinant mouse Rnf111 (Arkadia), recruited to recombinant human SKI/SKIL bound to TGF-beta-activated SMAD2/3, ubiquitinates SKI/SKIL transcriptional repressors (Levy et al. 2007, Nagano et al. 2007).

Literature References
PubMed ID Title Journal Year
17510063 Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

Nagano, Y, Mavrakis, KJ, Lee, KL, Fujii, T, Koinuma, D, Sase, H, Yuki, K, Isogaya, K, Saitoh, M, Imamura, T, Episkopou, V, Miyazono, K, Miyazawa, K

J Biol Chem 2007
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS

Mol Cell Biol 2007
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created