Formation of CSL NCOR corepressor complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Mammalian CSL Corepressor Complexes: In the absence of activated Notch signaling, DNA-bound CSL proteins recruit a corepressor complex to maintain target genes in the repressed state until Notch is specifically activated. The mammalian corepressor complexes include NCOR complexes, but may also include additional corepressor proteins, such as SHARP (reviewed in Mumm, 2000 and Kovall, 2007). The exact composition of the CSL NCOR complex is not known, but in other pathways the "core" NCOR corepressor complex includes at least one NCOR protein (NCOR1, NCOR2, CIR), one Histone Deacetylase protein (HDAC1, HDAC3, or certain others), and one TBL1 protein (TBL1X, TBL1XR1) (reviewed in Rosenfeld, 2006). In some contexts, the core NCOR corepressor complex may also recruit additional corepressor proteins or complexes, such as the SIN3 complex, which consists of SIN3 (SIN3A, SIN3B), and SAP30, or other SIN3-associated proteins. An additional CSL - NCOR binding corepressor, SHARP, may also contribute to the CSL corepressor complex in some contexts (Oswald, 2002). The CSL corepressor complex also includes a bifunctional cofactor, SKIP, that is present in both CSL corepressor complexes and CSL coactivator complexes, and may function in the binding of NICD and displacement of the corepressor complex during activated Notch signaling (Zhou, 2000). The formation of the CSL-NCOR corepressor complexes is modelled here as the simultaneous assembly of the various components shown. The order of addition of components is not known, and may vary in different contexts.

Literature References
PubMed ID Title Journal Year
12374742 SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

Dillinger, K, Oswald, F, Zechner, U, Liptay, S, Ludwig, L, Kostezka, U, Knöchel, W, Hameister, H, Bourteele, S, Schmid, RM, Wilda, M, Astrahantseff, K

EMBO J 2002
11112321 Notch signaling: from the outside in

Kopan, R, Mumm, JS

Dev Biol 2000
16530045 Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA

Kovall, RA, Wilson, JJ

Cell 2006
10713164 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

Zhou, S, Weinmaster, G, Hayward, SD, Miyamoto, A, Chen, L, Fujimuro, M, Hsieh, JJ

Mol Cell Biol 2000
16751179 Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

Lunyak, VV, Glass, CK, Rosenfeld, MG

Genes Dev 2006
Orthologous Events
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