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MEAF6 [nucleoplasm]
Stable Identifier
R-HSA-3318448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromatin modification-related protein MEAF6, EAF6_HUMAN, EAF6
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)
KAT6:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)
KAT7:ING4,5 dimers:MEAF6:PHF17,(15,16) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
NuA4 complex acetylates histone H2A, HIST1H4 (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
AKT phosphorylates KAT6A (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT6A acetylates TP53 (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT6A and PML bind TP53 (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
MEAF6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HAF1 MEAF6
Gene Names
MEAF6, C1orf149, CENP-28, EAF6
Chain
initiator methionine:1, chain:2-191
Reference Genes
BioGPS Gene:64769 MEAF6
COSMIC (genes):MEAF6 MEAF6
CTD Gene:64769 MEAF6
dbSNP Gene:64769 MEAF6
ENSEMBL:ENSG00000163875 MEAF6
HGNC:25674 MEAF6
KEGG Gene (Homo sapiens):64769 MEAF6
Monarch:64769 MEAF6
NCBI Gene:64769 MEAF6
OMIM:611001 MEAF6
UCSC:Q9HAF1 MEAF6
Reference Transcript
RefSeq:NM_001270875.1 MEAF6
RefSeq:NM_022756.5 MEAF6
RefSeq:NM_001270876.1 MEAF6
Other Identifiers
0001980465
11722376_at
11746164_a_at
11756418_a_at
16685362
218165_PM_at
218165_at
228517_PM_at
228517_at
230293_PM_at
230293_at
2407129
2407130
2407131
2407132
2407133
2407134
2407135
2407136
2407137
2407138
2407140
2407141
2407147
2407149
2407150
2407151
2407154
2407155
2407157
2407158
2407159
2407160
2525488
56040_r_at
57683_at
64769
78675_at
7914994
7914996
A_23_P103442
A_24_P268015
A_32_P32905
GE82717
GE881633
GO:0000123
GO:0000775
GO:0000776
GO:0000786
GO:0001558
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006259
GO:0006275
GO:0006325
GO:0006355
GO:0006464
GO:0006950
GO:0007049
GO:0008150
GO:0008219
GO:0009058
GO:0016570
GO:0016573
GO:0032991
GO:0034641
GO:0035267
GO:0040007
GO:0042981
GO:0043226
GO:0043967
GO:0043968
GO:0043981
GO:0043982
GO:0043983
GO:0044154
GO:0045893
GO:0048856
GO:0050793
GO:0051276
GO:0051726
GO:0070776
GO:1903706
GO:1905168
GO:2000278
GO:2000779
HMNXSV003007256
HMNXSV003038762
Hs.269853.0.A1_3p_at
Hs.65857.0.A1_3p_at
ILMN_1714854
ILMN_2076940
PH_hs_0001557
TC01002517.hg
g12232424_3p_at
Participates
as a component of
KAT7:ING4,5 dimers:MEAF6:PHF17,(15,16) [nucleoplasm] (Homo sapiens)
NuA4 [nucleoplasm] (Homo sapiens)
KAT6:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
Inferred To
Eaf6 [nucleoplasm]
(Drosophila melanogaster)
eaf6 [nucleoplasm]
(Schizosaccharomyces pombe)
Meaf6 [nucleoplasm]
(Mus musculus)
Meaf6 [nucleoplasm]
(Rattus norvegicus)
MEAF6 [nucleoplasm]
(Bos taurus)
MEAF6 [nucleoplasm]
(Canis familiaris)
MEAF6 [nucleoplasm]
(Dictyostelium discoideum)
MEAF6 [nucleoplasm]
(Gallus gallus)
MEAF6 [nucleoplasm]
(Sus scrofa)
meaf6 [nucleoplasm]
(Danio rerio)
meaf6 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_073593.2
,
NP_001257804.1
,
NP_001257805.1
OpenTargets
ENSG00000163875
GeneCards
Q9HAF1
HPA
ENSG00000163875-MEAF6
Ensembl
ENST00000448519
,
ENSP00000394966
,
ENSP00000362164
,
ENST00000373073
,
ENST00000296214
,
ENSP00000296214
,
ENST00000373075
,
ENSG00000163875
,
ENSP00000362166
PRO
Q9HAF1
Pharos - Targets
Q9HAF1
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
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