Reactome | MEAF6 [nucleoplasm]

MEAF6 [nucleoplasm]

Stable Identifier

R-HSA-3318448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromatin modification-related protein MEAF6, EAF6_HUMAN, EAF6

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HAF1 MEAF6

Gene Names

MEAF6, C1orf149, CENP-28, EAF6

Chain

initiator methionine:1, chain:2-191

Reference Genes

BioGPS Gene:64769 MEAF6

COSMIC (genes):MEAF6 MEAF6

CTD Gene:64769 MEAF6

dbSNP Gene:64769 MEAF6

ENSEMBL:ENSG00000163875 MEAF6

HGNC:25674 MEAF6

KEGG Gene (Homo sapiens):64769 MEAF6

Monarch:64769 MEAF6

NCBI Gene:64769 MEAF6

OMIM:611001 MEAF6

UCSC:Q9HAF1 MEAF6

Reference Transcript

Other Identifiers

0001980465

11722376_at

11746164_a_at

11756418_a_at

16685362

218165_at

228517_at

2407132

2407133

2407134

2407135

2407136

2407137

2407138

2407140

2407141

2407147

2407149

2407150

2407151

2407154

2407155

2525488

56040_r_at

64769

78675_at

7914996

A_23_P103442

A_24_P268015

GE82717

GO:0000123

GO:0000775

GO:0000776

GO:0000777

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006325

GO:0006464

GO:0007165

GO:0008150

GO:0016573

GO:0016746

GO:0032991

GO:0035267

GO:0043226

GO:0043968

GO:0043972

GO:0043981

GO:0043982

GO:0043983

GO:0043994

GO:0044154

GO:0051276

GO:0070776

GO:1901796

GO:1990467

GO:1990468

Hs.269853.0.A1_3p_at

ILMN_1714854

ILMN_2076940

PH_hs_0001557

TC01002517.hg

g12232424_3p_at

Participant Of

hasComponent

Inferred To

Eaf6 [nucleoplasm] (Drosophila melanogaster)

eaf6 [nucleoplasm] (Schizosaccharomyces pombe)

EAF6 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of MEAF6 [nucleoplasm] (Gallus gallus)

Meaf6 [nucleoplasm] (Mus musculus)

Meaf6 [nucleoplasm] (Rattus norvegicus)

MEAF6 [nucleoplasm] (Bos taurus)

MEAF6 [nucleoplasm] (Canis familiaris)

MEAF6 [nucleoplasm] (Dictyostelium discoideum)

MEAF6 [nucleoplasm] (Sus scrofa)

meaf6 [nucleoplasm] (Danio rerio)

meaf6 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001257804.1, NP_001257805.1, NP_073593.2

OpenTargets

ENSG00000163875

HPA

ENSG00000163875-MEAF6

GeneCards

Q9HAF1

Ensembl

ENSP00000296214, ENSP00000394966, ENSP00000362166, ENST00000373073, ENSG00000163875, ENST00000373075, ENST00000296214, ENSP00000362164, ENST00000448519

PRO

Q9HAF1

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.666	4
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3