Reactome | MEAF6 [nucleoplasm]

MEAF6 [nucleoplasm]

Stable Identifier

R-HSA-3318448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromatin modification-related protein MEAF6, EAF6_HUMAN, EAF6

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        MEAF6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HAF1 MEAF6

Gene Names

MEAF6, C1orf149, CENP-28, EAF6

Chain

initiator methionine:, chain:2-191

Reference Genes

BioGPS Gene:64769 MEAF6

COSMIC (genes):MEAF6 MEAF6

CTD Gene:64769 MEAF6

dbSNP Gene:64769 MEAF6

ENSEMBL:ENSG00000163875 MEAF6

HGNC:25674 MEAF6

KEGG:hsa:64769 MEAF6

Monarch:64769 MEAF6

NCBI Gene:64769 MEAF6

OMIM:611001 MEAF6

UCSC:Q9HAF1 MEAF6

Reference Transcript

Other Identifiers

11722376_at

11746164_a_at

11756418_a_at

16685362

218165_PM_at

218165_at

228517_PM_at

228517_at

230293_PM_at

230293_at

2407129

2407130

2407131

2407132

2407133

2407134

2407135

2407136

2407137

2407138

2407140

2407141

2407144

2407145

2407146

2407147

2407149

2407150

2407151

2407152

2407153

2407154

2407155

2407157

2407158

2407159

2407160

2525488

56040_r_at

57683_at

64769

78675_at

7914994

7914996

A_23_P103442

A_24_P268015

A_32_P32905

GE82717

GE881633

GO:0000123

GO:0000775

GO:0000776

GO:0000786

GO:0001558

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0006275

GO:0006325

GO:0006338

GO:0006355

GO:0016740

GO:0035267

GO:0036408

GO:0042981

GO:0043226

GO:0043995

GO:0043996

GO:0043997

GO:0045893

GO:0050793

GO:0051726

GO:0070776

GO:0140096

GO:1903706

GO:1905168

GO:2000278

GO:2000779

HMNXSV003007256

HMNXSV003038762

HMNXSV003043819

Hs.269853.0.A1_3p_at

Hs.65857.0.A1_3p_at

ILMN_1714854

ILMN_2076940

PH_hs_0001557

TC01002517.hg

g12232424_3p_at

Participates

as a component of

Inferred To

Eaf6 [nucleoplasm] (Drosophila melanogaster)

eaf6 [nucleoplasm] (Schizosaccharomyces pombe)

Meaf6 [nucleoplasm] (Mus musculus)

Meaf6 [nucleoplasm] (Rattus norvegicus)

MEAF6 [nucleoplasm] (Bos taurus)

MEAF6 [nucleoplasm] (Caenorhabditis elegans)

MEAF6 [nucleoplasm] (Canis familiaris)

MEAF6 [nucleoplasm] (Dictyostelium discoideum)

MEAF6 [nucleoplasm] (Gallus gallus)

MEAF6 [nucleoplasm] (Sus scrofa)

meaf6 [nucleoplasm] (Danio rerio)

meaf6 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000373073, ENSG00000163875, ENSP00000394966, ENSP00000362164, ENST00000373075, ENST00000448519, ENSP00000362166, ENSP00000296214, ENST00000296214

OpenTargets

ENSG00000163875

GeneCards

MEAF6

HPA

ENSG00000163875-MEAF6

PRO

Q9HAF1

Pharos - Targets

Q9HAF1

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.743	5
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	3
UniProt:Q9H2F5 EPC1	1	EPC1 [nucleoplasm] (R-HSA-3321978)	0.527	4