ATF7IP binds SETDB1

Stable Identifier
R-HSA-5159250
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SETDB1 (ESET, KMT1E) is one of several protein lysine methyltransferases which selectively methylate lysine-10 of the amino terminus of histone H3 (H3K9) (Rea et al. 2000). It is most effective when complexed with ATF7IP (MCAF, hAM) (Wang et al. 2003).

Literature References
PubMed ID Title Journal Year
14536086 mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression

Wang, H, An, W, Cao, R, Xia, L, Erdjument-Bromage, H, Chatton, B, Tempst, P, Roeder, RG, Zhang, Y

Mol. Cell 2003
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