EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP

Stable Identifier
R-HSA-9844111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP
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Either EHMT2 (also called G9a) or EHMT1 (also called GLP) can trimethylate lysine-16 of ATF7IP (inferred from mouse homologs in Tsusaka et al. 2018). Lysine-16 of ATF7IP is located in a domain that mimics lysine-9 of histone H3, which is also methylated by EHMT2 and EHMT1. Trimethylation of ATF7IP is required for interaction of ATF7IP with MPHOSPH8 (MPP8) of the HUSH complex (inferred from mouse homologs in Tsusaka et al. 2018).
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Catalyst Activity

protein-lysine N-methyltransferase activity of EHMT1,2 [nucleoplasm]

Physical Entity
EHMT1,2 [nucleoplasm] (Homo sapiens)
Activity
protein-lysine N-methyltransferase activity (GO:0016279)
Inferred From
Ehmt1,Ehmt2 trimethylates lysine-16 of Atf7ip (Mus musculus)
Authored
May, B  (2023-09-12)
Reviewed
Bourc'his, D  (2024-05-14)
Fernandes, LP  (2024-05-14)
Created
May, B  (2023-09-12)
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